Table 1 Experimental group data (oxonic acid feeding period from week 3 to 12)

Systolic blood pressure

Week 3 (before treatment)

119 ± 4

120 ± 5

128 ± 5

127 ± 5

Week 12

133 ± 7

135 ± 5

141 ± 6^‡

151 ± 5^‡

Body weight (g)

Week 3

341 ± 6

337 ± 8

335 ± 8

331 ± 7

Week 12

436 ± 9

411 ± 12^#

452 ± 11

412 ± 30^#

Heart weight (g/kg) at the end of study

Right ventricle

0.28 ± 0.01

0.29 ± 0.01

0.34 ± 0.03^‡

0.33 ± 0.03^‡

Left ventricle

1.71 ± 0.06

1.86 ± 0.06

2.23 ± 0.11*^‡

2.41 ± 0.18*^‡

Removed kidney tissue (g/kg)

7.67 ± 0.17

7.50 ± 0.08

Uric acid (μmol/l)

33.5 ± 11.8

121.6 ± 22.4*

64.4 ± 21.0

156.7 ± 20.2*^†

Creatinine (μmol/l)

40.1 ± 5.7

49.3 ± 3.2

80.7 ± 3.2*^‡

81.8 ± 8.8*^‡

Urea (mmol/l)

6.5 ± 0.4

8.3 ± 0.5

12.9 ± 0.6*^‡

14.3 ± 2.2*^‡