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Table 1 Experimental group data (oxonic acid feeding period from week 3 to 12)

From: Effects of oxonic acid-induced hyperuricemia on mesenteric artery tone and cardiac load in experimental renal insufficiency

  Sham Sham + Oxo NX NX + Oxo
Systolic blood pressure     
Week 3 (before treatment) 119 ± 4 120 ± 5 128 ± 5 127 ± 5
Week 12 133 ± 7 135 ± 5 141 ± 6 151 ± 5
Body weight (g)     
Week 3 341 ± 6 337 ± 8 335 ± 8 331 ± 7
Week 12 436 ± 9 411 ± 12# 452 ± 11 412 ± 30#
Heart weight (g/kg) at the end of study     
Right ventricle 0.28 ± 0.01 0.29 ± 0.01 0.34 ± 0.03 0.33 ± 0.03
Left ventricle 1.71 ± 0.06 1.86 ± 0.06 2.23 ± 0.11* 2.41 ± 0.18*
Removed kidney tissue (g/kg)    7.67 ± 0.17 7.50 ± 0.08
Uric acid (μmol/l) 33.5 ± 11.8 121.6 ± 22.4* 64.4 ± 21.0 156.7 ± 20.2*
Creatinine (μmol/l) 40.1 ± 5.7 49.3 ± 3.2 80.7 ± 3.2* 81.8 ± 8.8*
Urea (mmol/l) 6.5 ± 0.4 8.3 ± 0.5 12.9 ± 0.6* 14.3 ± 2.2*
  1. Values are mean ± SEM; n = 11, except for laboratory values in the Sham group n = 9. *P < 0.05 compared with the Sham group, P < 0.05 compared with the NX group using one-way ANOVA; P < 0.05 NX groups compared with the Sham groups using two-way ANOVA; #P < 0.05 Sham+Oxo and NX+Oxo groups compared with the Sham and NX groups using two-way ANOVA.