Skip to main content

Table 1 Study characteristics

From: Urate lowering therapy to improve renal outcomes in patients with chronic kidney disease: systematic review and meta-analysis

First author (Ref No.) Year of publication Journal Location of trial Study design Duration of follow-up Sample size Treatment Control
Katholi [51] 1998 American Journal of Kidney Diseases Springfield, Illinois Parallel Group RCT with 2x2 factorial design 2 days 39 Allopurinol Placebo
Perez-Ruiz [56] 1999 Journal of Clinical Rheumatology Pais Vasco, Spain Parallel Group RCT 9-12 months 36 Benzbromarone Allopurinol
Kamper [50] 2001 Clinical Transplantation Herlev, Denmark Cross-over RCT 2 weeks 26 Losartan No treatment
Schmidt [53] 2001 Nephrology Dialysis Transplantation Vienna, Austria Cross-over RCT 3 weeks 13 Losartan Enalapril
Doehner [35] 2002 Circulation London, UK Cross-over RCT 2 weeks 14 Allopurinol Placebo
Chanard [54] 2003 Nephrology Dialysis Transplantation Three centres in France Parallel Group RCT 2 months 48 Amlodipine Tertatolol
Siu [48] 2006 American Journal of Kidney Diseases Hong Kong, China Parallel Group RCT 12 months 54 Allopurinol No treatment
Liu [36] 2007 China Pharmacy Guangzhou and Luzhou, China Parallel Group RCT 12 months 47 Allopurinol No treatment
Sarris [34] 2007 Nephrology Dialysis Transplantation Athens, Greece Parallel Group RCT 12 months 36 Allopurinol No treatment
Lei [40] 2009 Shaanxi Medical Journal Xi’an, China Parallel Group RCT 12 months 57 Allopurinol No treatment
Malaguarnera [55] 2009 Expert Opinion Pharmacotherapy Catania, Italy Parallel Group RCT 2 months 38 Rasburicase Placebo
Nouri-Majalan [52] 2009 Vascular Health and Risk Management Yazd, Iran Parallel Group RCT 5 days 60 Allopurinol and vitamin E No treatment
Deng [37] 2010 Journal of Practical Medicine Beijing, China Parallel Group RCT 12 months 68 Allopurinol No treatment
Goicoechea [44] 2010 Clinical Journal of American Soc of Neph Madrid, Spain Parallel Group RCT 24 months 113 Allopurinol No treatment
Momeni [46] 2010 Iranian Journal of Kidney Diseases Isfahan, Iran Parallel Group RCT 4 months 44 Allopurinol Placebo
Shen [38] 2010 China Foreign Medical Treatment Chengdu, China Parallel Group RCT 12 months 52 Allopurinol No treatment
Kao [45] 2011 Journal of American Soc of Neph Dundee, UK Parallel Group RCT 9 months 67 Allopurinol Placebo
Tan [39] 2011 Modern Hospital Guangzhou, China Parallel Group RCT 24 months 140 Allopurinol No treatment
Shi [47] 2012 Kidney and Blood Pressure Research Guangzhou, China Parallel Group RCT 6 months 40 Allopurinol No treatment