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Table 1 Schedule of measurements and activities by visit for the PACE study

From: Rationale and design for the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) study

 

Baseline visit

Follow-up (FU) Visits and Telephone (T) Contacts

 

EV

BV

T4

T6

T8

FU12

T16

T18

T20

FU24

Up to FU48

Interviewer/Questionnaires §

           

Informed consent

          

Contact information

  

 

 

 

Sociodemographic

          

Education and employment

 

   

   

Vascular access

 

   

   

Residual kidney function

 

   

   

Dialysis prescription

 

   

   

Dialysis adherence

 

   

   

Pre-dialysis education

 

   

   

Medical history

  

 

 

 

Family history of CVD, SCD

          

Female reproductive history

 

   

   

Health, behaviour, social history

    

   

Access to transplant

    

   

KDQOL-36

 

   

   

Symptomatic CVD (Rose, KCQ)

 

   

   

Physical activity

 

   

   

Dietary questions & 24-hr recall

 

 

 

Literacy (WRAT4)

 

         

Cognition (Trails A&B, 3MS)

 

   

   

Depression (PHQ9)

 

   

   

Oral medications

 

   

   

Examination

           

Height, weight, BMI, WHR

 

   

   

Blood pressures

 

   

   

Detailed amputation evaluation

 

   

   

Frailty assessment

 

   

   

Procedures

           

CT calcium and angiography

 

         

Echocardiography

 

         

Pulse wave velocity

 

   

   

12 lead & signal averaged ECG

 

   

   

4 Limb ankle brachial

 

   

   

Blood tests (fasting)

           

Ionized calcium, magnesium

 

   

   

Repository (DNA, RNA, blood, nails)

 

   

   

Clinical

           

Baseline charlson co-morbidity

          

CMS-2728 medical evidence

          

Hospitalizations

Throughout the entire study period

CMS-2746 death notification

Collect as needed

Dialysis routine bloods (monthly)

Throughout the entire study period

Glucose, albumin

           

Complete blood count

           

Electrolytes (Na, K, Mg, CO2, Ca, Phos)*

           

Intact PTH*

           

Fe, TIBC, Ferritin, Aluminum*

           

URR, spKt/V, nPCR*

           

Dialysis treatments (weekly) ‡‡

Throughout the entire study period

Dry weight

           

Dialysis bath (Ca, K, HCO3)*

           

Prescription (duration, frequency, dialyzer)

           

Pre and post weights

           

Pre and post blood pressures (BP)

           

Dialysis flow rate

           

Blood flow rate

           

Intravenous medications

           
  1. §KCQ = Kansas City Questionnaire; KDQOL-36 = Kidney Disease Quality of Life 36 Item Instrument; WRAT4 = Wide Range Achievement Test 4th Edition; Trails A&B; 3MS = Modified Mini-Mental Status Exam; PHQ9 = Patient Health Questionnaire 9; ¶BMI = Body Mass Index; WHR = Waist Hip Ratio; Blood Pressure is collected as 3 seated Blood Pressures; ‡Collected as needed; *Na- sodium K- potassium; Ca- calcium; Phos- phosphorus; HCO3- bicarbonate; PTH- parathyroid hormone level; Fe- iron; TIBC- total iron binding capacity; URR- urea reduction ratio; nPCR- nitrogen protein catabolic rate; ‡‡Dialysis Machine Derived Parameters: BP-pre, BP-post, Lowest BP, Weight-pre, Weight-post, Intradialytic Weight Gain, & Average Blood Flow Rate.