End stage renal disease as a modifier of the periodontal microbiome

BMC Nephrology

Table 2 Comparison of clinical, demographic, alpha diversity, and CKD-related variables of ESRD-O and ESRD-C subgroups

Characteristic	ESRD-O (n = 6)	ESRD-C (n = 8)	p-value
	Demographic data
Age (years)^a	64.3 ± 13.4	55.8 ± 18.7	0.07
Gender (% male) (n)^c	83.0 (5)	37.5 (3)	<0.001
Ethnicity (% non-whites) (n)^c	67.0 (4)	25.0 (2)	<0.001
	Periodontal data
PD (mm)^§	3.0 ± 0.7	3.0 ± 0.5	0.50
CAL (mm)^a	3.6 ± 1.0	3.8 ± 1.7	0.35
BoP (% of sites)^a	40.0 ± 28.0	29.0 ± 20.0	0.40
PS (% of sites)^a	73.0 ± 28.0	72.0 ± 28.0	0.89
PD ≥ 5 mm (% of sites)^b	12.0 (5.0-45.0)	6.0 (3.0-36.0)	0.37
	Alpha diversity
Number of observed OTUs^a	101.8 ± 40.7	181.8 ± 39.0	0.004
Estimated OTUs^a	169.0 ± 93.6	287.1 ± 68.3	0.029
Inverse simpson index^a	8.1 ± 5.8	19.5 ± 11.7	0.036
NP-Shannon Index^a	2.5 ± 1.2	3.7 ± 0.5	0.049
Shannon evenness^a	0.5 ± 0.2	0.7 ± 0.1	1.00
	CKD-related variables
Dialysis vintage (years)^b	2.0 (1.25-4.0)	1 (1.0-5.0)	0.78
Antibiotic prophylaxis (% yes) (n)^c	67.0 (4)	25.0 (2)	0.28
Albumin levels (g/dL)^b	4.3 (3.7-4.4)	4.0 (3.0-4.3)	0.07
Diabetes status (% yes) (n)^c	50.0 (3)	50.0 (4)	1.00
Dialysis adequacy (kt/V) ^b	1.56 ± 0.18	1.85 ± 0.46	0.67
BUN (mg/dL)^a	59.33 ± 13.04	55.05 ± 18.26	0.36

Data represent mean ± standard deviation for normally distributed data, median (interquartile range) for non-normally distributed data, or frequencies (%) for dichotomous data
PD pocket depth; CAL clinical attachment level; BoP bleeding on probing; PS: plaque score; mm millimeters; OTUs: Operational Taxonomic Units; g/dL: grams per deciliter; mg/dL: milligrams per deciliter
Statistical Tests: Independent t-test (^a); Mann Whitney (^b); Chi-square test (^c)

ISSN: 1471-2369