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Table 5 Discrimination and calibration statistics for chronic kidney diseases (CKD) risk model performance in subgroups of participants by gender, age and body mass index (BMI), for the outcome of CKD based on CKD-EPI equation predicted glomerular filtration rate with or without proteinuria

From: Validation of two prediction models of undiagnosed chronic kidney disease in mixed-ancestry South Africans

Models (outcome)

 

Men

Women

Age < 60 years

Age ≥ 60 years

BMI < 25 kg/m2

BMI ≥ 25 kg/m2

Thai model (eGFR < 60 ml/min/1.73 m2)

E/O (95 % CI)

1.38 (0.99-1.92)

0.97 (0.82-1.13)

2.14 (1.49-3.08)

0.84 (0.72-0.99)

0.96 (0.72-1.28)

1.08 (0.91-1.27)

Brier score

0.105

0.132

0.056

0.242

0.106

0.133

Yates slope

0.254

0.206

0.019

0.076

0.246

0.199

C-statistic (95 % CI)

0.850 (0.787-0.912)

0.802 (0.764-0.840)

0.573 (0.479-0.667)

0.614 (0.556-0.673)

0.872 (0.820-0.923)

0.784 (0.742-0.826)

Korean model (eGFR < 60 ml/min/1.73 m2)

E/O (95 % CI)

0.88 (0.63-1.23)

0.78 (0.82-1.13)

1.25 (0.87-1.80)

0.72 (0.61-0.84)

0.73 (0.55-0.98)

0.83 (0.91-1.27)

Brier score

0.098

0.131

0.049

0.247

0.110

0.128

Yates slope

0.221

0.208

0.031

0.082

0.231

0.203

C-statistic (95 % CI)

0.887 (0.835-0.939)

0.842 (0.807-0.876)

0.676 (0.587-0.766)

0.674 (0.617-0.730)

0.891 (0.844-0.937)

0.833 (0.797-0.870)

Thai model (eGFR < 60 ml/min/1.73 m2 or proteinuria)

E/O (95 % CI)

1.44 (1.03-2.01)

0.95 (0.81-1.10)

2.05 (1.45-2.90)

0.84 (0.97-0.72)

0.95 (0.72-1.25)

0.82 (0.70-0.97)

Brier score

0.106

0.133

0.059

0.240

0.106

0.135

Yates slope

0.259

0.220

0.038

0.085

0.264

0.208

C-statistic (95 % CI)

0.850 (0.787-0.912)

0.817 (0.781-0.853)

0.611 (0.517-0.705)

0.632 (0.574-0.690)

0.887 (0.839-0.935)

0.793 (0.753-0.834)

Korean mdel (eGFR < 60 ml/min/1.73 m2 or proteinuria)

E/O (95 % CI)

0.92 (0.66-1.29)

0.77 (0.66-0.89)

1.20 (0.85-1.70)

0.71 (0.61-0.83)

0.72 (0.55-0.95)

0.82 (0.70-0.97)

Brier score

0.097

0.130

0.051

0.241

0.108

0.128

Yates slope

0.229

0.230

0.055

0.100

0.257

0.218

 

C-statistic (95 % CI)

0.887 (0.835-0.939)

0.858 (0.825-0.890)

0.709 (0.622-0.797)

0.700 (0.645-0.755)

0.907 (0.864-0.950)

0.844 (0.808-0.880)

  1. eGFR, estimated glomerular filtration rate; E/O, Expected/Observed event rate; 95 % CI: 95 % confidence interval