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Table 4 Association of chronic kidney disease (CKD) with HBV, stratified by sex and age, with adjustment for competing mortality

From: 13-year nationwide cohort study of chronic kidney disease risk among treatment-naïve patients with chronic hepatitis B in Taiwan

 

HBV cohort

Non-HBV cohort

 

Hazard ratio (95 % CI)

 

n

PY

CKD events

n

PY

CKD events

Crude

P

Adjusted*

P

Sex

  Men

10428

68249

294

41712

274693

525

2.26 (1.96–2.61)

<0.001

3.05 (2.50–3.71)†

<0.001

  Women

7368

48243

131

29472

192357

297

1.77 (1.44–2.18)

<0.001

2.56 (1.93–3.41)†

<0.001

Age (year)

  < 50

13428

84358

203

53712

337813

191

4.30 (3.53–5.24)

<0.001

2.86 (1.98–4.13)

<0.001

  50

4368

32133

222

17472

129237

631

1.40 (1.20–1.63)

<0.001

1.19 (0.90–1.56)

0.22

Men

  < 50 years

7888

49981

140

31552

200858

132

4.28 (3.38–5.43)

<0.001

2.98 (2.32–3.83)

<0.001

  50 years

2540

18268

154

10160

73835

393

1.57 (1.30–1.89)

<0.001

1.58 (1.31–1.91)

<0.001

Women

  < 50 years

5540

34378

63

22160

136955

59

4.34 (3.05–6.19)

<0.001

2.99 (2.04–4.42)

<0.001

  50 years

1828

13865

68

7312

55402

238

1.13 (0.86–1.48)

0.37

1.18 (0.90–1.55)

0.24

  1. Abbreviations: HBV hepatitis B virus, PY person-year, CI confidence interval
  2. *Adjusted for all covariates (age, sex, major comorbidities, use of herbs containing aristolochic acid, geographic region, urbanization level, enrollee category, number of medical visits, Charlson Comorbidity Index score, and propensity score) and interaction terms (HBV/age, HBV/sex, HBV/age/sex), minus the covariate and interaction terms on which stratified
  3. †Age was treated as a continuous variable in multivariate analysis