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Table 1 Baseline characteristics of the cohort overall and stratified on relative and absolute interdialytic weight gain

From: A retrospective, longitudinal study estimating the association between interdialytic weight gain and cardiovascular events and death in hemodialysis patients

Variablea Overall N = 39,256 Relative IDWG Absolute IDWG
   ≤3.5 % n = 24,726 >3.5 % n = 14,530 p-value ≤3.0 kg n = 28,942 >3.0 kg n = 10,314 p-value
Age, year 62.2 ± 15.3 63.0 ± 15.0 60.7 ± 15.6 <0.001 63.7 ± (15.3 57.9 ± 14.2 <0.001
Female sex 17,238 (43.9) 11,462 (46.4) 5776 (39.8 %) <0.001 14,180 (49.0) 3058 (29.7) <0.001
Race     <0.001    <0.001
White 18,055 (46.0) 11,975 (48.5) 6080 (41.9)   13,358 (46.2) 4697 (45.6)  
Black 12,437 (31.7) 7951 (32.2) 4486 (30.9) 9008 (31.1) 3429 (33.3)
Hispanic 5777 (14.7) 3153 (12.8) 2624 (18.1) 4279 (14.8) 1498 (14.5)
Asian 1260 (3.2) 635 (2.6) 625 (4.3) 1044 (3.6) 216 (2.1)
Other 984 (2.5) 586 (2.4) 398 (2.7) 742 (2.6) 242 (2.4)
ESRD etiology     <0.001    <0.001
Diabetes 18,500 (47.1) 11,068 (44.8) 7432 (51.2)   12,649 (43.7) 5851 (56.7)  
Hypertension 11,942 (30.4) 7834 (31.7) 4108 (28.3) 9361 (32.3) 2581 (25.0)
Glomerular disease 2825 (7.2) 1927 (7.8) 898 (6.2) 2190 (7.6) 635 (6.2)
Other 5989 (15.3) 3897 (15.8) 2082 (14.4) 4742 (16.4) 1247 (12.1)
Prior renal txp 697 (1.8) 366 (1.5) 331 (2.3) <0.001 507 (1.8) 190 (1.8) 0.55
Baseline diabetesb 26,768 (68.2) 16,337 (66.1) 10,431 (71.8) <0.001 18,765 (64.8) 8003 (77.6) <0.001
Baseline CHFb 15,623 (39.8) 9340 (37.8) 6283 (43.2) <0.001 11,008 (38.0) 4615 (44.8) <0.001
Baseline MIb 9920 (25.3) 6238 (25.2) 3682 (25.3) 0.81 7274 (25.1) 2646 (25.7) 0.30
Baseline AFb 2310 (5.9) 1433 (5.8) 877 (6.0) 0.33 1720 (5.9) 590 (5.7) 0.41
Baseline CVDc 3404 (8.7) 2129 (8.6) 1275 (8.8) 0.58 2560 (8.9) 844 (8.2) 0.04
Uncontrolled hypertensiond 37,283 (95.0) 23,492 (95.0) 13,791 (94.9) 0.68 27,464 (94.9) 9819 (95.2) 0.22
Vascular access     <0.001    <0.001
AVF 10,787 (27.7) 6826 (27.6) 4052 (27.9)   7728 (26.7) 3150 (30.6)  
AVG 3782 (9.6) 2269 (9.2) 1513 (10.4) 2776 (9.6) 1006 (9.8)
CVC 24,573 (62.6) 15,616 (63.2) 8957 (61.7) 18,420 (63.7) 6153 (59.7)
Postdialysis weight, kg 77.0 (34.7) 80.3 (41.2) 71.4 (17.8) <0.001 73.3 (37.2) 87.4 (23.5) <0.001
  1. Abbreviations: AF atrial fibrillation, CHF congestive heart failure, CVD cerebrovascular disease, AVF arteriovenous fistula, AVG arteriovenous graft, CVC central venous catheter, ESRD end-stage renal disease, IDWG interdialytic weight gain, MI myocardial infarction, txp transplant
  2. aValues expressed as mean ± SD or n (%)
  3. bDefined based on CMS Medical Evidence Form 2728 data, claims (1 inpatient or 2 outpatient), or LDO EHR records prior to dialysis day 180
  4. cDefined based on CMS Medical Evidence Form 2728, claims (1 inpatient or 2 outpatient), LDO EHR record prior to dialysis day 180. Includes ischemic stroke, hemorrhagic stroke, and TIA
  5. dDefined as mean predialysis blood pressure > 140/90 mm Hg or postdialysis blood pressure > 130/85 mm Hg during the outcome period (dialysis days 91–180)