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Table 2 Association between two-fold higher baseline plasma Lp(a) levels and eGFR decline

From: Relation of atherogenic lipoproteins with estimated glomerular filtration rate decline: a longitudinal study

Analysis

eGFR decline, ml/min/1.73 m2 (95 % CI)

P-Value

Model 1

−0.83 (−0.97, −0.70)

<0.001

Model 2

−0.51 (−0.65, −0.37)

<0.001

Model 3

−0.50 (−0.64, −0.36)

<0.001

  1. Data represent eGFR change per year for every two-fold higher plasma Lp(a) concentration, analyzed as a continuous variable. Regression through mixed effects modeling was performed in incremental models with the following co-variates
  2. Model 1: Age, gender, race, baseline SCr
  3. Model 2: Age, gender, race, baseline SCr, BMI, hypertension, lipid-lowering medications, smoking, alcohol use, hemoglobin A1c
  4. Model 3: Age, gender, race, baseline SCr, BMI, hypertension, lipid-lowering medications, smoking, alcohol use, hemoglobin A1c, urinary ACR
  5. *Definition of hypertension includes the use of anti-hypertensive medications
  6. SCr serum creatinine, ACR albumin to creatinine ratio
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BMC Nephrology

ISSN: 1471-2369

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