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Table 3 Association between Two-fold Higher Baseline ApoC-III and eGFR Decline

From: Relation of atherogenic lipoproteins with estimated glomerular filtration rate decline: a longitudinal study

Analysis

eGFR decline, ml/min/1.73 m2 (95 % CI)

P-Value

Model 1

−1.62 (−1.93, −1.31)

<0.001

Model 2

−0.46 (−0.80, −0.13)

0.007

Model 3

−0.38 (−0.72, −0.05)

0.026

Model 4

−0.22 (−0.60, 0.16)

0.257

  1. Data represent eGFR change per year for every two-fold increase of log-transformed plasma apoC-III concentration, analyzed as a continuous variable. Linear regression through mixed effects modeling was performed in incremental models with the following co-variates
  2. Model 1: Age, gender, race, baseline SCr
  3. Model 2: Age, gender, race, baseline SCr, BMI, hypertension, lipid-lowering medications, smoking, alcohol use, hemoglobin A1c
  4. Model 3: Age, gender, race, baseline SCr, BMI, hypertension, lipid-lowering medications, smoking, alcohol use, hemoglobin A1c, urinary ACR
  5. Model 4: Age, gender, race, baseline SCr, BMI, hypertension, lipid-lowering medications, smoking, alcohol use, hemoglobin A1c, urinary ACR, triglyceride levels
  6. *Definition of hypertension includes the use of anti-hypertensive medications
  7. SCr serum creatinine, ACR albumin to creatinine ratio
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BMC Nephrology

ISSN: 1471-2369

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