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Fig. 4 | BMC Nephrology

Fig. 4

From: Membranoproliferative glomerulonephritis with predominant IgG2 and IgG3 deposition in a patient with IgG4-related disease

Fig. 4

Immunohistochemical staining for IgG4 in lip and kidney biopsies. a Immunohistochemical staining for CD138 in a lip biopsy specimen. b IgG4 staining in the lip using serial section. In the glandular area, diffuse infiltration of IgG4-positive plasma cells is observed, and an IgG4/CD138 ratio is approximately 85 %. c Immunohistochemical staining for IgG in a kidney biopsy specimen. d IgG4 staining in the kidney using serial section revealed several foci of IgG4-positive cells in the interstitium. The IgG4/IgG ratio is approximately 90 %. Original magnification, × 400. e–h Glomeruli showing predominant IgG2 and IgG3 (IgG3 > IgG2) deposition in the mesangial area and capillary loop. Deposition of IgG1 is negative, and IgG4 shows weak and segmental deposition

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BMC Nephrology

ISSN: 1471-2369

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