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Table 2 Performance of the different eGFR equations

From: The chronic kidney disease epidemiology collaboration equation combining creatinine and cystatin C accurately assesses renal function in patients with cirrhosis

Performance

CG

MDRD

CKD-EPI-Cr

Hoek

Larsson

CKD-EPI CysC

CKD-EPI-Cr-CysC

All Cirrhotics [N = 50] mGFR 89.6 ± 27.5

       

 eGFR

130.4 ± 41.0

101.1 ± 26.5

99.0 ± 18.5

78.0 ± 25.8

81.0 ± 31.3

80.9 ± 29.0

89.0 ± 24.8

 Bias

−40.8 ± 29.2

−11.5 ± 22.0

−9.4 ± 20.7

11.1 ± 15.8

8.1 ± 17.7

8.2 ± 17.7

0.1 ± 16.3

 Accuracy 10 %

4 %*

36 %

38 %

39 %

41 %

41 %

49 %

 Accuracy 30 %

36 %*

74 %

78 %

84 %

82 %

84 %

84 %

 CC (Pearson) (95 % CI)

0.703 (0.52–0.82)

0.688 (0.50–0.81)

0.658 (0.46–0.79)

0.862 (0.77–0.92)

0.826 (0.71–0.89)

0.805 (0.68–0.88)

0.812 (0.69–0.89)

 CCC (95 % CI)

0.383* (0.25–0.52)

0.611* (0.45–0.77)

0.563* (0.40–0.72)

0.757 (0.64–0.87)

0.789 (0.68–0.89)

0.771 (0.66–0.88)

0.807 (0.70–0.90)

CTP A [N = 18] mGFR 97.2 ± 24.1

       

 eGFR

126.6 ± 37.9

100.0 ± 26.1

99.7 ± 19.2

83.8 ± 25.2

88.0 ± 31.0

88.1 ± 27.6

93.8 ± 24.6

 Bias

−29.4 ± 21.6

−2.8 ± 16.1

−2.5 ± 15.4

13.3 ± 12.3

9.2 ± 15.3

9.1 ± 12.6

3.4 ± 11.1

 Accuracy 10 %

6 %

61 %

50 %

39 %

44 %

39 %

67 %

 Accuracy 30 %

56 %

89 %

94 %

89 %

89 %

94 %

94 %

 CC (Pearson) (95 % CI)

0.851 (0.64–0.94)

0.798 (0.53–0.80)

0.771 (0.48–0.91)

0.877 (0.69–0.95)

0.875 (0.69–0.95)

0.889 (0.72–0.96)

0.896 (0.74–0.96)

 CCC (95 % CI)

0.529* (0.32–0.74)

0.790 (0.61–0.97)

0.746 (0.54–0.95)

0.785 (0.58–0.93)

0.801 (0.65–0.95)

0.827 (0.69–0.97)

0.887 (0.78–0.99)

CTP B [N = 18] mGFR 89.1 ± 25.2

       

 eGFR

142.7 ± 45.1

106.3 ± 22.7

102.9 ± 13.4

83.2 ± 20.4

86.7 ± 24.7

88.3 ± 25.3

95.4 ± 20.2

 Bias

−53.7 ± 31.9

−17.2 ± 23.3

−13.8 ± 20.6

5.9 ± 20.1

2.3 ± 21.7

0.8 ± 21.7

−6.3 ± 19.1

 Accuracy 10 %

0 %

22 %

33 %

44 %

44 %

44 %

39 %

 Accuracy 30 %

28 %

67 %

78 %

83 %

78 %

78 %

78 %

 CC (Pearson) (95 % CI)

0.725 (0.39–0.89)

0.534 (0.09–0.80)

0.581 (0.16–0.82)

0.628 (0.23–0.85)

0.623 (0.22–0.84)

0.632 (0.23–0.85)

0.667 (0.29–0.87)

 CCC (95 % CI)

0.288 (0.10–0.48)

0.417 (0.10–0.74)

0.387 (0.11–0.66)

0.594 (0.30–0.89)

0.620 (0.32–0.92)

0.631 (0.34–0.93)

0.625 (0.35–0.90)

CTP C [N = 14] mGFR 80.4 ± 32.8

       

 eGFR

119.2 ± 37.9

95.8 ± 31.9

93.1 ± 22.7

62.9 ± 32.8

63.2 ± 35.2

60.5 ± 27.5

73.3 ± 25.6

 Bias

−38.8 ± 29.4

−15.4 ± 24.8

−12.7 ± 25.4

15.1 ± 12.2

14.7 ± 12.5

17.4 ± 13.5

4.6 ± 16.3

 Accuracy 10 %

7 %

21 %

29 %

31 %

31 %

38 %

38 %

 Accuracy 30 %

21 %

64 %

57 %

77 %

77 %

77 %

77 %

 CC (Pearson) (95 % CI)

0.663 (0.20–0.88)

0.706 (0.28–0.90)

0.635 (0.16–0.87)

0.930 (0.79–0.98)

0.934 (0.80–0.98)

0.915 (0.75–0.97)

0.872 (0.64–0.96)

 CCC (95 % CI)

0.399 (0.10–0.69)

0.629 (0.32–0.94)

0.535 (0.20–0.87)

0.816 (0.66–0.98)

0.846 (0.70–0.99)

0.764 (0.57–0.96)

0.835 (0.67–0.99)

Controls [N = 24] mGF: 97.5 ± 15.1

       

 eGFR

98.7 ± 21.9

85.4 ± 12.9

93.5 ± 12.2

108.4 ± 17.9

118.9 ± 24.1

107.7 ± 13.6

102.1 ± 12.1

 Bias

−1.2 ± 19.8

12.1 ± 12.3

4.1 ± 10.6

−10.9 ± 19.5

−21.4 ± 24.2

−10.2 ± 12.1

−4.5 ± 9.5

 Accuracy 10 %

21 %*

16 %*

54.%

17 %*

37 %

54 %

71 %

 Accuracy 30 %

92 %

100 %

100 %

83 %

62 %*

87 %

91 %

 CC (Pearson) (95 % CI)

0.481 (0.09–0.74)

0.622 (0.29–0.82)

0.718 (0.44–0.87)

0.314* (−0.10–0.64)

0.303* (−0.11–0.62)

0.649 (0.33–0.83)

0.778 (0.54–0.89)

 CCC (95 % CI)

0.449 (0.14–0.80)

0.443 (0.19–0.68)

0.671 (0.46–0.88)

0.252* (−0.06–0.57)

0.171* (−0.06–0.40)

0.510 (0.26–0.76)

0.718 (0.53–0.90)

  1. mGFR and eGFR are expressed as means ± standard deviation in mL/min/1.73 m2; CC, correlation coefficient; CCC, concordance correlation coefficient. * p < 0.05; statistical significant differences between CDK-EPI-Cr-CysC and other eGFR equations