Fig. 3

Genes studied for association with either susceptibility to AKI (S) or AKI outcome (O). Red color indicates positive association signals (based on the interpretation of the authors themselves), where dark red signals higher (≥8) quality score and light red signals lower quality score (3–7). Blue color indicates no association. Articles are presented alphabetically by the fist author and genes are presented in alphabetical order. Abbreviations: ACE, Angiotensin Converting Enzyme gene; AGTR1, Angiotensin II Receptor, Type 1 gene; AGT, Angiotensinogen gene; APOE, Apolipoprotein-E gene; BCL-2, B-cell CLL/lymphoma 2 gene; COMT, Catechol-O-methyltransferase gene; CYBA, Cytochrome b₂₄₅, α subunit gene; eNOS, endothelial Nitric Oxide Synthase gene; EPO, Erythropoietin gene; FCGR2A, Receptor IIa of the Fc portion of immunoglobulin G gene; FCGR3A, Receptor IIIa of the Fc portion of immunoglobulin G gene; FCGR3B, Receptor IIIb of the Fc portion of immunoglobulin G gene; GLI1, Gli family zinc finger 1 gene; HHIP, Hedgehog Interacting Protein gene; HIF-1-alpha, Hypoxia-Inducible Factor 1-alpha gene; HLA-DRB1, Human Leukocyte Antigen – Major Histocompatibility Complex, Class II, DR beta 1 gene; IL-6, Interleukin-6 gene; IL-8, Interleukin-8; IL-10, Interleukin-10 gene; LTA, Lymphotoxin Alpha gene; MPO, Myeloperoxidase gene; NADPH, Nicotinamide Adenosine Dinucleotide Phosphate gene; PBEF, Pre-B cell colony-enhancing factor gene; PNMT, Phenylethanolamine N-methyltransferase gene; PTCH1, Patched homolog 1 gene; PTCH2, Patched homolog 2 gene; SERPINA4, Serpin Peptidase Inhibitor, Clade A (alpha-1 antiproteinase, antitrypsin) Member 4 gene; SERPINA5, Serpin Peptidase Inhibitor, Clade A (alpha-1 antiproteinase, antitrypsin) Member 5 gene; SIK3, Salt-Inducible Kinase 3 gene; SMO, Smoothened gene; SUFU, Suppressor of Fused homolog gene; TGF-β, Transient Growth Factor beta gene; TNFA, Tumor Necrosis Factor alpha gene; VEGF, Vascular Endothelial Growth Factor gene