From: Low dose of mycophenolate mofetil is enough in desensitized kidney transplantation using rituximab
Low dose MMF | Conventional dose MMF | p1a | p2b | ||
---|---|---|---|---|---|
Rituximab(+) | Rituximab(+) | Rituximab(−) | |||
Group 1 (n = 72) | Group 2 (n = 67) | Group 3 (n = 87) | |||
Sex (male/female) | 34/38 | 42/25 | 46/41 | 0.088 | 0.526 |
Age (years) | 40.92 ± 10.20 | 44.88 ± 11.65 | 42.72 ± 10.39 | 0.034 | 0.273 |
Dialysis (hemo/peritoneal) | 50/13 | 57/6 | 54/13 | 0.134 | 1.000 |
Dialysis duration (months) | 24.95 ± 30.20 | 32.11 ± 33.47 | 31.04 ± 39.09 | 0.210 | 0.324 |
Etiology of ESRD | 0.043 | 0.006 | |||
Diabetes mellitus | 13 | 14 | 21 | ||
Hypertension | 11 | 12 | 23 | ||
Glomerulonephritis | 33 | 16 | 14 | ||
Vesicoureteral reflux | 0 | 4 | 1 | ||
Polycystic kidney disease | 3 | 5 | 5 | ||
Unknown etiology | 11 | 11 | 15 | ||
Other causes | 1 | 5 | 7 | ||
Past medical history | |||||
Diabetes mellitus | 14 | 15 | 23 | 0.682 | 0.348 |
Hypertension | 59 | 57 | 73 | 0.655 | 0.833 |
Hepatitis | 4 | 6 | 2 | 0.522 | 0.411 |
Autoimmune disease | 3 | 0 | 1 | 0.246 | 0.329 |
Malignancy history | 1 | 3 | 0 | 0.352 | 0.453 |
Mean follow up time (months) | 14.89 ± 6.01 | 12.63 ± 7.59 | 14.05 ± 8.17 | 0.053 | 0.455 |
ABO compatibility/T-flow | 0.255 | ||||
ABO incompatible | 47 | 36 | - | ||
/T-flow(−) | |||||
ABO compatible | 14 | 21 | - | ||
/T-flow(+) | |||||
ABO incompatible | 11 | 10 | - | ||
/T-flow(+) | |||||
Donor to recipient | 0.159 | ||||
Compatible | 14 | 21 | 87 | ||
A → B | 6 | 11 | - | ||
B → A | 9 | 8 | - | ||
A/B → O | 24 | 18 | - | ||
AB → A/B/O | 19 | 9 | - | ||
HLA mismatch | 3/7/13/14/10/19/6 | 4/0/7/20/7/18/11 | 4/2/12/25/14/19/11 | 0.065 | 0.335 |
(0/1/2/3/4/5/6) | |||||
HLA class I mismatch | 5/14/25/16/12 | 4/5/27/14/17 | 5/8/34/23/17 | 0.260 | 0.441 |
(0/1/2/3/4/) | |||||
HLA class II mismatch | 13/32/27 | 6/33/28 | 10/49/28 | 0.296 | 0.275 |
(0/1/2/) | |||||
Donor sex (male/female) | 39/33 | 34/33 | 46/41 | 0.735 | 0.875 |
Donor age (years) | 39.63 ± 10.95 | 41.88 ± 11.65 | 43.00 ± 9.90 | 0.241 | 0.043 |
Donor’s relation with recipient | 0.822 | 0.011 | |||
Parents | 8 | 7 | 8 | ||
Siblings | 17 | 20 | 36 | ||
Children | 14 | 11 | 6 | ||
Spouse | 27 | 21 | 22 | ||
Others | 6 | 8 | 15 | ||
CMV IgG serostatus | 0.178 | 0.590 | |||
Donor+/Recipient+ | 70 (97.2 %) | 65 (97.0 %) | 86 (98.9 %) | ||
Donor+/Recipient- | 0 (0.0 %) | 2 (3.0 %) | 0 (0 %) | ||
Donor-/Recipient+ | 2 (2.8 %) | 0 (0.0 %) | 1 (1.1 %) |