From: Low dose of mycophenolate mofetil is enough in desensitized kidney transplantation using rituximab
Low dose MMF | Conventional dose MMF | p1a | p2b | ||
---|---|---|---|---|---|
Rituximab(+) | Rituximab(+) | Rituximab(−) | |||
Group 1 | Group 2 | Group 3 | |||
(n = 72) | (n = 67) | (n = 87) | |||
Tacrolimus drug levels (ng/ml) | |||||
Pre KT (72/67/87) | 6.99 ± 2.57 | 9.56 ± 4.75 | 11.11 ± 6.58 | <0.001 | <0.001 |
After 1 month (72/65/87) | 7.74 ± 3.53 | 9.17 ± 3.22 | 7.65 ± 2.89 | 0.015 | 0.847 |
After 3 months (71/55/86) | 7.19 ± 2.79 | 7.64 ± 2.54 | 7.58 ± 2.76 | 0.349 | 0.380 |
After 6 months (71/48/71) | 6.66 ± 2.50 | 7.11 ± 2.11 | 6.83 ± 2.19 | 0.304 | 0.664 |
After 1 year (49/39/48) | 5.77 ± 1.81 | 6.57 ± 2.13 | 5.77 ± 2.16 | 0.060 | 0.987 |
After 2 years (6/4/15) | 7.18 ± 1.28 | 5.48 ± 1.81 | 5.51 ± 3.16 | 0.116 | 0.228 |
Mycophenolate mofetil doses (g/day) | |||||
Pre KT (72/67/87) | 1.44 ± 0.15 | 1.51 ± 0.29 | 1.55 ± 0.17 | 0.071 | <0.001 |
After 1 week (72/66/87) | 1.03 ± 0.19 | 1.48 ± 0.34 | 1.48 ± 0.32 | <0.001 | <0.001 |
After 2 weeks (72/66/87) | 1.00 ± 0.15 | 1.42 ± 0.39 | 1.48 ± 0.31 | <0.001 | <0.001 |
After 3 weeks (72/66/87) | 1.00 ± 0.17 | 1.39 ± 0.41 | 1.46 ± 0.32 | <0.001 | <0.001 |
After 1 month (72/65/87) | 0.95 ± 0.24 | 1.26 ± 0.42 | 1.40 ± 0.39 | <0.001 | <0.001 |
After 3 months (71/55/86) | 0.93 ± 0.30 | 1.14 ± 0.51 | 1.35 ± 0.38 | 0.007 | <0.001 |
After 6 months (71/48/71) | 0.94 ± 0.26 | 1.07 ± 0.50 | 1.24 ± 0.47 | 0.095 | <0.001 |
After 1 year (49/39/47) | 0.93 ± 0.28 | 0.88 ± 0.52 | 1.23 ± 0.41 | 0.637 | <0.001 |
After 2 years (6/4/16) | 1.08 ± 0.20 | 0.69 ± 0.55 | 1.28 ± 0.45 | 0.252 | 0.313 |
Methyl-prednisolone doses (mg/day) | |||||
Pre KT (72/67/87) | 16.00 ± 0.00 | 16.84 ± 6.01 | 15.91 ± 0.86 | 0.259 | 0.365 |
After 1 month (72/65/87) | 11.11 ± 1.68 | 11.97 ± 2.31 | 11.59 ± 2.70 | 0.015 | 0.195 |
After 3 months (71/55/86) | 8.03 ± 1.49 | 9.09 ± 1.48 | 8.16 ± 2.06 | <0.001 | 0.637 |
After 6 months (71/48/71) | 6.25 ± 1.82 | 7.33 ± 1.39 | 6.87 ± 3.59 | 0.001 | 0.197 |
After 1 year (49/39/48) | 4.61 ± 1.48 | 5.33 ± 1.80 | 5.96 ± 8.71 | 0.042 | 0.289 |
After 2 years (6/4/16) | 3.00 ± 2.45 | 4.00 ± 0.00 | 3.75 ± 1.44 | 0.447 | 0.505 |