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Table 2 Doses of immunosuppressants

From: Low dose of mycophenolate mofetil is enough in desensitized kidney transplantation using rituximab

 

Low dose MMF

Conventional dose MMF

p1a

p2b

 

Rituximab(+)

Rituximab(+)

Rituximab(−)

 

Group 1

Group 2

Group 3

(n = 72)

(n = 67)

(n = 87)

Tacrolimus drug levels (ng/ml)

 Pre KT (72/67/87)

6.99 ± 2.57

9.56 ± 4.75

11.11 ± 6.58

<0.001

<0.001

 After 1 month (72/65/87)

7.74 ± 3.53

9.17 ± 3.22

7.65 ± 2.89

0.015

0.847

 After 3 months (71/55/86)

7.19 ± 2.79

7.64 ± 2.54

7.58 ± 2.76

0.349

0.380

 After 6 months (71/48/71)

6.66 ± 2.50

7.11 ± 2.11

6.83 ± 2.19

0.304

0.664

 After 1 year (49/39/48)

5.77 ± 1.81

6.57 ± 2.13

5.77 ± 2.16

0.060

0.987

 After 2 years (6/4/15)

7.18 ± 1.28

5.48 ± 1.81

5.51 ± 3.16

0.116

0.228

Mycophenolate mofetil doses (g/day)

 Pre KT (72/67/87)

1.44 ± 0.15

1.51 ± 0.29

1.55 ± 0.17

0.071

<0.001

 After 1 week (72/66/87)

1.03 ± 0.19

1.48 ± 0.34

1.48 ± 0.32

<0.001

<0.001

 After 2 weeks (72/66/87)

1.00 ± 0.15

1.42 ± 0.39

1.48 ± 0.31

<0.001

<0.001

 After 3 weeks (72/66/87)

1.00 ± 0.17

1.39 ± 0.41

1.46 ± 0.32

<0.001

<0.001

 After 1 month (72/65/87)

0.95 ± 0.24

1.26 ± 0.42

1.40 ± 0.39

<0.001

<0.001

 After 3 months (71/55/86)

0.93 ± 0.30

1.14 ± 0.51

1.35 ± 0.38

0.007

<0.001

 After 6 months (71/48/71)

0.94 ± 0.26

1.07 ± 0.50

1.24 ± 0.47

0.095

<0.001

 After 1 year (49/39/47)

0.93 ± 0.28

0.88 ± 0.52

1.23 ± 0.41

0.637

<0.001

 After 2 years (6/4/16)

1.08 ± 0.20

0.69 ± 0.55

1.28 ± 0.45

0.252

0.313

Methyl-prednisolone doses (mg/day)

 Pre KT (72/67/87)

16.00 ± 0.00

16.84 ± 6.01

15.91 ± 0.86

0.259

0.365

 After 1 month (72/65/87)

11.11 ± 1.68

11.97 ± 2.31

11.59 ± 2.70

0.015

0.195

 After 3 months (71/55/86)

8.03 ± 1.49

9.09 ± 1.48

8.16 ± 2.06

<0.001

0.637

 After 6 months (71/48/71)

6.25 ± 1.82

7.33 ± 1.39

6.87 ± 3.59

0.001

0.197

 After 1 year (49/39/48)

4.61 ± 1.48

5.33 ± 1.80

5.96 ± 8.71

0.042

0.289

 After 2 years (6/4/16)

3.00 ± 2.45

4.00 ± 0.00

3.75 ± 1.44

0.447

0.505

  1. Abbreviations: KT kidney transplantation, MMF mycophenolate mofetil
  2. agroup 1 vs. group 2
  3. bgroup 1 vs. group 3