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Table 2 Cross-sectional association of GFR with self-reported frailty in the MDRD trial, using alternative measures of GFR

From: Association of Frailty based on self-reported physical function with directly measured kidney function and mortality

 

mGFR

eGFRcr

eGFRcys*

Odds Ratio (95 % CI)

Odds Ratio (95 % CI)

Odds Ratio (95 % CI)

 

Univariate

Multivariable

Univariate

Multivariable

Univariate

Multivariable

GFR, per 10 ml/min/1.73 m2

0.75 (0.63–0.89)

0.71 (0.60–0.86)

0.81 (0.68–0.94)

0.80 (0.67–0.94)

0.74 (0.62–0.88)

0.75 (0.62–0.90)

GFR in categories

GFR ≥45 (reference)

1.00

1.00

1.00

GFR 30–44

2.10 (1.09–4.00)

1.83 (0.93–3.60)

2.10 (1.04–4.20)

1.77 (0.87–3.60)

1.71 (0.82–3.60)

1.50 (0.70–3.20)

GFR ≤29

3.20 (1.71–5.90)

3.40 (1.77–6.50)

3.30 (1.72–6.50)

3.20 (1.61–6.40)

2.50 (1.25–5.00)

2.30 (1.11–4.70)

  1. Abbreviations: mGFR, measured glomerular filtration rate by Iothalamate; eGFRcr, creatinine estimated glomerular filtration rate; eGFRcys by CKD-EPI equation,* N = 797. All multivariate models are adjusted for urine protein, sex, age, race, body mass index and albumin quartiles