Skip to main content

Table 3 Odds ratios for having renal dysfunction after 7 and 13 years of observation when participants with baseline RD were not excluded (n = 2637)

From: Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: The Tromsø Study

Risk factors

Renal dysfunction° Tromsø 5 2001/02 (n = 474)

p-value

ACR ≥ 1.13 mg/mmol Tromsø 5 2001/02 (n = 394)

p- value

Estimated GFR <60 ml/min/1.73 m2 Tromsø 5, 2001/02 (n = 117)

p- value

Age, per 5 years increase

1.13 (1.02, 1.25)

0.02

1.19 (1.06, 1.33)

0.002

1.44 (1.15, 1.80)

<0.001

SUA increasersa

1.98 (1.52, 2.59)

<0.001

1.35 (1.018, 1.82)

0.044

4.85 (2.87, 8.19)

<0.001

Baseline SUA, per 59 μmol/L (1 mg/dl) increase

1.10 (0.99, 1.24)

0.09

1.05 (0.92, 1.18)

0.5

1.42 (1.15, 1.75)

0.001

Estimated GFR per 5 ml/1.73 m2 decrease

1.22 (1.17, 1.27)

<0.001

1.05 (0.99, 1.12)

0.16

1.44 (1.38, 1.49)

<0.001

Log ACR per unit

26.9 (18.3, 39.7)

<0.001

44.87 (29.57, 68.08)

<0.001

1.47 (0.86, 2.49)

0.16

 

Renal dysfunction Tromsø 6 2007/08 (n = 697)

 

ACR ≥ 1.13 mg/mmol Tromsø 6 2007/08 (n = 589)

 

Estimated GFR < 60 ml/min/1.73 m2 Tromsø 6, 2007/08 (n = 220)

 

Age, per 5 years increase

1.27 (1.17, 1.38)

<0.001

1.31 (1.19, 1.43)

<0.001

1.65 (1.39, 1.94)

<0.001

SUA increasersa

2.12 (1.71, 2.65)

<0.001

1.46 (1.16, 1.85)

<0.001

5.11 (3.45, 7,56)

<0.001

Baseline SUA, per 59 μmol/L (1 mg/dl) increase

1.15 (1.05, 1.26)

0.003

1.09 (0.99, 1.21)

0.09

1.35 (1.16, 1.58)

<0.001

Estimated GFR per 5 ml/1.73 m2 decrease

1.11 (1.06, 1.16)

<0.001

0.98 (0.92, 1.03)

0.5

1.38 (1.33, 1.43)

<0.001

Log ACR per unit

6.99 (5.16, 9.48)

<0.001

11.11(8.05, 15.32)

<0.001

1.60 (1.06, 2.41)

0.03

  1. ACR urinary albumin/creatinine ratio, SUA serum uric acid. °Renal dysfunction was defined as ACR ≥1.13 mg/mmol and/or estimated GFR <60 ml/min/1.73 m2. aSUA increasers: the upper tertile of change in SUA from baseline to follow-up, compared to the two lower tertiles. Multivariate adjustments were performed for systolic blood pressure, BMI, cholesterol, current smoking; physical activity, antihypertensive drugs included diuretics, diabetes, previous myocardial infarction and/or stroke and change in systolic blood pressure during follow-up. We also included start of antihypertensive treatment during observation, cessation of smoking during observation or becoming physically active during observation as independent variables