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Table 2 Association between serum bicarbonate level and renal hyperfiltration

From: Association between lower serum bicarbonate and renal hyperfiltration in the general population with preserved renal function: a cross-sectional study

 

Quintile groups of serum bicarbonate

Renal hyperfiltrationa (%)

Odds ratio (95 % confidence interval) for renal hyperfiltrationb

p for interaction

Total

 

1st

300/6550 (4.6)

1.39 (1.11 to 1.75)

 
  

2nd

322/7106 (4.5)

1.41 (1.13 to 1.76)

 
  

3rd

188/3885 (4.8)

1.55 (1.22 to 1.98)

 
  

4th

193/6110 (3.2)

1.02 (0.81 to 1.30)

 
  

5th

111/3801 (2.9)

Reference

 

Sex

Men

1st

128/3294 (3.9)

1.40 (1.01 to 1.93)

0.9999

  

2nd

145/3715 (3.9)

1.39 (1.02 to 1.97)

 
  

3rd

87/2067 (4.2)

1.51 (1.08 to 2.26)

 
  

4th

95/3411 (2.8)

1.00 (0.72 to 1.46)

 
  

5th

59/2235 (2.6)

Reference

 
 

Women

1st

172/3256 (5.3)

1.39 (1.01 to 1.93)

 
  

2nd

177/3391 (5.2)

1.43 (1.04 to 1.97)

 
  

3rd

101/1818 (5.6)

1.60 (1.13 to 2.26)

 
  

4th

98/2699 (3.6)

1.03 (0.73 to 1.46)

 
  

5th

52/1566 (3.3)

Reference

 

Age

Young

1st

194/3839 (5.1)

1.66 (1.18 to 2.32)

0.6341

  

2nd

192/3878 (5.0)

1.68 (1.21 to 2.35)

 
  

3rd

105/2040 (5.1)

1.81 (1.27 to 2.60)

 
  

4th

98/2986 (3.3)

1.18 (0.82 to 1.69)

 
  

5th

45/1704 (2.6)

Reference

 
 

Olderc

1st

106/2711 (3.9)

1.25 (0.91 to 1.72)

 
  

2nd

130/3228 (4.0)

1.25 (0.92 to 1.70)

 
  

3rd

83/1845 (4.5)

1.39 (1.00 to 1.94)

 
  

4th

95/3124 (3.0)

0.93 (0.68 to 1.28)

 
  

5th

66/2097 (3.1)

Reference

 

BMId

≤25 kg/m2

1st

168/4132 (4.1)

1.18 (0.89 to 1.56)

0.0907

  

2nd

199/4581 (4.3)

1.31 (1.00 to 1.71)

 
  

3rd

113/2528 (4.5)

1.40 (1.04 to 1.88)

 
  

4th

134/4066 (3.3)

1.04 (0.78 to 1.39)

 
  

5th

79/2643 (3.0)

Reference

 
 

>25 kg/m2

1st

132/2418 (5.5)

1.98 (1.32 to 2.95)

 
  

2nd

123/2525 (4.9)

1.72 (1.15 to 2.57)

 
  

3rd

75/1357 (5.5)

1.98 (1.30 to 3.03)

 
  

4th

59/2044 (2.9)

1.03 (0.66 to 1.60)

 
  

5th

32/1158 (2.8)

Reference

 
  1. aSee Methods for details
  2. bBy multivariate logistic regression analysis, adjusted for systolic blood pressure, alcohol intake, smoking status, regular exercise, medication for hypertension and/or diabetes, serum fasting glucose, serum uric acid, serum calcium, serum albumin, serum triglyceride, serum high density lipoprotein-cholesterol, and albuminuria, where age, sex, or body mass index were added as adjusted variables except for the variable of interest
  3. cOlder than the sex-specific median age, 51 years for women and 50 years for men
  4. dBody Mass Index