Table 2 Criteria for determining appropriateness of glomerulonephritis and paraprotein testing in AKI

A. Hematuria and/or Proteinuria (any of the following):

 • RBCs on urine microscopy >25 cells/hpf ^a

 • RBC cast(s) on urine sediment evaluation

 • ≥ 3+ proteinuria on urine dipstick or ≥ 1 g by quantification

B. Extra-renal manifestation (any of the following):

 • Cutaneous lesions (livedo reticularis or purpura)

 • Ear, nose, or throat manifestations such as sinusitis, epistaxis, or nasal ulcers

 • Pulmonary disease including hemoptysis or CXR showing patchy or diffuse opacities and with absence of an alternative etiology (e.g. pneumonia)

• Arthritis

C. Rapidly progressive AKI

 • Increase in serum Cr >100 % in less than 24 h, and absence of an alternative etiology

D. Known history of glomerulonephritis or vasculitis

A. Proteinuria

 • ≥ 3+ on urine dipstick or ≥ 1 g by quantification

B. Known history of a plasma cell dyscrasia (including any of the following):

• Monoclonal gammopathy of undetermined significance

• Smoldering myeloma

• Multiple myeloma

• Waldenstroms Macroglobulinemia

• Serum free light chain ratio ≥ 100^b

C. Hypercalcemia of unknown etiology

• > 11 mg/dl^b

D. Anemia of unknown etiology

• Hemoglobin < 10 g/dl^b

E. Bone lesions

• One or more osteolytic lesions on skeletal radiography, CT, or PET-CT^b