New congenital anomalies of the kidney and urinary tract and outcomes in Robo2 mutant mice with the inserted piggyBac transposon

Table 1 Penetrance of CAKUT in Robo2 mutant mice

	CAKUT penetrance (%)	VUR		Renal Hypo/dysplasia	Hydronephrosis	DS/multiple e ureter	UPJO	UVJO
	CAKUT penetrance (%)	Dilating VUR	Simple VUR	Renal Hypo/dysplasia	Hydronephrosis	DS/multiple e ureter	UPJO	UVJO
Robo2 ^del5/del5	20/20 (100 %)-14/14 (100 %)	Not reported	Not reported	20/20 (100 %)	Not reported	12/14 (86 %)	Not reported	Not reported
Robo2 ^del5/+	4/26 (15 %) Unilateral CAKUT-VUR	4/26 (15 %) megaureter and a wide- open UVJ,	Not reported	Not reported	Not reported	Not reported	Not reported	Wide-open UVJ and megaureter
Robo2 ^del5/del5↔Robo2 ^del5/flox mosaic	4/10 (40 %)-7/10 (70 %) unilateral CAKUT	Not reported	Not reported	Large cyst	Severe hydronephrosis and short ureter megaureter	Not reported	Not reported	Bilateral UVJ defects, located laterally and cephalad in the bladder
Robo2 ^PB/PB	78/229 (34.06 %)	13/229 (5.68 %)	62/229 (27.07 %,)	10/229 (4.37 %)	8/229 (3.49 %)	5/229 (2.18 %,)	3/229 (1.31 %)	1/229 (0.44 %)
wild-type (Robo2 ^+/+)	8/117 (6.84 %)	0	8/117 (6.84 %)	0	0	0	0	0

Because there were only a small number of such mice, the results obtained with newborn Robo2 ^+/+; Hoxb7/myr-Venus and Robo2 ^PB/PB; Hoxb7/myr-Venus mice were not included
DS duplex collecting system, UPJO ureteropelvic junction obstruction, UVJ ureterovesical junction obstruction, VUR vesicoureteral reflux

ISSN: 1471-2369