Table 3 The change (>2-fold change, p < 0.05) of fibrosis-related genes in CLU KO kidneys compared to WT controls after 30 days of IRI
Gene (protein) | Fold change in KO kidneys vs. WT controls | p value (n = 4) | Main functions |
|---|---|---|---|
Egf (Epidermal growth factor) | −2.7208 | 0.0341 | The growth of epidermal and epithelial cells, and some of fibroblasts |
ccl12 (Chemokine (C-C Motif) ligand 12) | 2.1439 | 0.0130 | The recruitment of monocytes, lymphocytes and fibrocytes |
col3a1 (Collagen, Type III, alpha 1) | 2.0162 | 0.0457 | Fibril forming |
mmp9 (Matrix metallopeptidase 9) | 2.573 | 0.0132 | The degradation of the extracellular matrix |
timp1 (Tissue inhibitor of metalloproteinase 1) | 2.0831 | 0.0260 | Inhibition of the matrix metalloproteinases |