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Table 1 Schedule of measurements and activities by visit for the ISAR study

From: Rationale and study design of the prospective, longitudinal, observational cohort study “rISk strAtification in end-stage renal disease” (ISAR) study

 

Baseline examination

Follow-up (FU) visits

 

T O (inclusion in the study)

T 24 months

T 6y

Interviewer/Questionaires

 Informed consent

X

  

 contact information

X

X

X

 sociodemographic

X

X

X

 Education and employment

X

X

X

 Vascular access

X

X

X

 Residual kidney function

X

X

X

 Dialysis prescription

X

X

X

 medical history

X

X

X

 cardiovascular risk factors

X

X

X

 Family history of CVD

X

X

X

 history of prior transplantations

X

X

X

 Physical activity

X

X

X

 MOCA

X

X

X

 CDR

X

X

X

 Restless legs score

X

X

X

 Oral medications

X

X

X

Examination

 Height, weight, BMI, upper arm circumference

X

X

X

 Blood pressure

X

X

X

Procedures

 12-lead holter ECG (24h)

X

  

 24-h holter blood pressure

X

  

 Pulse wave velocity (single measurement)

 

X

X

 Pulse wave analysis (single measurement)

 

X

X

 Pulse wave velocity (24h)

X

  

 Pulse wave analysis (24h)

X

  

 Retinal vessel analysis (static examination)

X

  

 Retinal vessel analysis (dynamic examination)

X

  

Blood tests (prior to dialysis, fasting), midweek dialysis session

 Serum blood sampling (frozen at −80 °C)

X

X

X

 EDTA blood sampling (frozen at −80°)

X

X

X

Clinical follow up

 Hospitalizations (cardiovascular, infectious…)

 

X

X

 cardiovascular events

 

X

X

 cardiovascular mortality

 

X

X

 total mortality

 

X

X

dialysis routine blood work (quarterly)

 Glucose, albumin

X

X

X

 complete blood count

X

X

X

 Electrolytes (Na, K, Mg, Ca, Phos)

X

X

X

 Blood gas analysis

X

X

X

 intact PTH

X

X

X

 Iron status

X

X

X

 Kt/V

X

X

X

Dialysis treatments

 Dry weight

X

X

X

 dialysis prescription (duration, frequency, dialyzer)

X

X

X

 Pre- and Post weights

X

X

X

 Dialysis flow rates

X

X

X

 Blood flow rates

X

X

X

 intravenous medications within dialysis session

X

X

X