Quantitative characterization of T-cell repertoire and biomarkers in kidney transplant rejection

BMC Nephrology

Table 2 Clinical characteristics of all seven patient with TCMR

ID	Age, Y	Gender	Race	Type of transplant	Cause of ESRD	cPRA	DSA	Induction	Time to rejection (months)	Type of TCMR	Reason for rejection
1	60–65	Male	African American	DDRT	HTN	0	DR53 Flowcytometric cross match level	Thymoglobulin	19	2A	BK viremia/lower immunosuppression
2	30–35	Male	White	DDRT	Diabetic nephropathy	0	De novo DQA5 Below flowcytometric crossmatch	Thymoglobulin	11	1A	Lower dose of MMF
3	20–25	Female	White	LRT	IgA nephropathy	0	De novo DSA: DR7, DR53, DQA3, DQB2, and DQB7 positive cytotoxic crossmatch	Thymoglobulin	21	1B
4	40–45	Female	White	LRT	Lupus nephritis	9%	Negative	Thymoglobulin	1	1A	Lower dose of MMF
5	45–50	Female	Asian	LRT	Unclear Etiology	10%	Negative	IL2 antagonist	3	1A
6	55–60	Female	Asian	DDRT	Chronic glomerular nephropathy	0	Negative	IL2 antagonist	3	1A
7	40–45	Female	Asian	LRT	Diabetic nephropathy	70%	Negative	IL2 antagonist	35	1A

cPRA calculated Panel Reactive Antibodies, DSA Donor Specific Antibodies, TCMD T cell mediated rejection, DDRT deceased donor renal transplant, HTN hypertension, MMF mycophenolate mofetil, LRT living donor renal transplant

ISSN: 1471-2369