Table 2 Urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine exosomal activating transcriptional factor 3 (uATF3) performances with predetermined cutoff points
Times | Sensitivity | Specificity | LR+ | LR- | PPV | NPV |
|---|---|---|---|---|---|---|
uNGAL | ||||||
 Cutoff 100 ng/mL | ||||||
  Baseline | 57.1 | 23.2 | 0.7 | 1.9 | 7.6 | 83.0 |
  Day-1 | 98.2 | 36.4 | 0.7 | 1.3 | 12.1 | 88.0 |
  Day + 1 | 90.0 | 28.1 | 1.3 | 0.7 | 13.8 | 93.1 |
  Day + 2 | 100.0 | 35.4 | 1.6 | 0.0 | 14.7 | 100.0 |
 Cutoff 150 ng/mL | ||||||
  Baseline | 52.2 | 34.4 | 0.8 | 1.6 | 9.2 | 85.2 |
  Day-1 | 97.5 | 44.3 | 1.8 | 0.2 | 16.5 | 96.7 |
  Day + 1 | 71.4 | 36.3 | 1.9 | 0.5 | 16.9 | 95.1 |
  Day + 2 | 83.3 | 50.2 | 1.7 | 0.3 | 16.0 | 96.5 |
uATF3 | ||||||
 Cutoff 6 ng/mL | ||||||
  Baseline | 57.1 | 73.2 | 2.1 | 0.6 | 19.1 | 93.9 |
  Day-1 | 42.9 | 73.2 | 1.6 | 0.8 | 15.1 | 92.0 |
  Day + 1 | 71.4 | 80.0 | 2.3 | 0.4 | 20.0 | 95.6 |
  Day + 2 | 71.4 | 90.2 | 7.3 | 0.3 | 44.9 | 96.6 |
 Cutoff 12 ng/mL | ||||||
  Baseline | 57.1 | 80.2 | 5.8 | 0.5 | 39.4 | 95.0 |
  Day-1 | 93.3 | 85.4 | 5.7 | 0.2 | 38.8 | 97.9 |
  Day + 1 | 90.9 | 88.2 | 5.7 | 0.5 | 38.2 | 98.9 |
  Day + 2 | 84.6 | 67.5 | 4.7 | 0.5 | 37.8 | 95.5 |