Skip to main content

Table 2 Urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine exosomal activating transcriptional factor 3 (uATF3) performances with predetermined cutoff points

From: Urinary exosomal activating transcriptional factor 3 as the early diagnostic biomarker for sepsis-induced acute kidney injury

Times Sensitivity Specificity LR+ LR- PPV NPV
uNGAL
 Cutoff 100 ng/mL
  Baseline 57.1 23.2 0.7 1.9 7.6 83.0
  Day-1 98.2 36.4 0.7 1.3 12.1 88.0
  Day + 1 90.0 28.1 1.3 0.7 13.8 93.1
  Day + 2 100.0 35.4 1.6 0.0 14.7 100.0
 Cutoff 150 ng/mL
  Baseline 52.2 34.4 0.8 1.6 9.2 85.2
  Day-1 97.5 44.3 1.8 0.2 16.5 96.7
  Day + 1 71.4 36.3 1.9 0.5 16.9 95.1
  Day + 2 83.3 50.2 1.7 0.3 16.0 96.5
uATF3
 Cutoff 6 ng/mL
  Baseline 57.1 73.2 2.1 0.6 19.1 93.9
  Day-1 42.9 73.2 1.6 0.8 15.1 92.0
  Day + 1 71.4 80.0 2.3 0.4 20.0 95.6
  Day + 2 71.4 90.2 7.3 0.3 44.9 96.6
 Cutoff 12 ng/mL
  Baseline 57.1 80.2 5.8 0.5 39.4 95.0
  Day-1 93.3 85.4 5.7 0.2 38.8 97.9
  Day + 1 90.9 88.2 5.7 0.5 38.2 98.9
  Day + 2 84.6 67.5 4.7 0.5 37.8 95.5
  1. LR, likelihood ratio; PPV, positive predictive value; NPV, negative predictive value
  2. Day-1 = the day before AKI was diagnosed, Day + 1 = the day after AKI was diagnosed, Day + 2 = the second day after AKI was diagnosed