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Table 2 Crude and multiple Cox regression analysis of body composition surrogates, ghrelin and their interactions for predicting all cause and cardiovascular mortality in the study population (n = 261)

From: Interaction between acyl-ghrelin and BMI predicts clinical outcomes in hemodialysis patients

 

Crude

Adjusteda

Variable

HR

95% CI

p

HR

95% CI

p

All-cause mortality

AG (>128.5 pg/ml)

0.73

0.50–1.07

0.10

0.67

0.45–1.00

0.05

BMI (>26.8 kg/m2)

0.62

0.42–-0.91

0.015

0.58

0.38–0.88

0.01

FM (>22.6 kg)

0.57

0.39–0.85

0.005

0.53

0.34–0.82

0.005

LBM (>48.7 kg)

0.83

0.56–1.23

0.35

0.88

0.54–1.42

0.59

Cre (>7.18 mg/dl)

0.50

0.34–0.73

<0.001

0.57

0.37–0.89

0.01

MAMC (>23.2 cm)

0.65

0.44–0.96

0.03

0.67

0.44–1.03

0.06

BMI*AGb

0.52

0.29–0.95

0.033

0.46

0.25–0.85

0.01

FM* AG

0.53

0.29–0.96

0.038

0.69

0.53–0.92

0.01

TSF* AG

0.42

0.23–0.78

0.006

0.61

0.45–0.82

0.001

LBM* AG

0.95

0.56–1.62

0.85

0.86

0.65–1.13

0.27

Cr* AG

0.87

0.50–1.52

0.63

0.81

0.62–1.05

0.11

MAMC* AG

0.96

0.96–1.02

0.45

0.79

0.58–1.06

0.12

Cardiovascular mortality

AG (>128.5 pg/ml)

0.70

0.40–1.23

0.22

0.73

0.40–1.31

0.29

BMI (>26.8 kg/m2)

0.57

0.32–1.00

0.05

0.56

0.30–1.03

0.06

FM (>22.6 kg)

0.43

0.24–0.79

0.006

0.43

0.22–0.83

0.01

TSF (>14.0 mm)

0.62

0.35–1.07

0.09

0.76

0.40–1.44

0.39

LBM (>48.7 kg)

1.25

0.71–2.19

0.44

0.99

0.50–1.96

0.98

Cr (>7.18 mg/dl)

0.58

0.33–1.01

0.05

0.51

0.28–0.95

0.03

MAMC (>23.2 cm)

0.69

0.40–1.20

0.19

0.61

0.34–1.11

0.11

BMI* AGb

0.58

0.24–1.38

0.22

0.58

0.24–1.43

0.24

FM* AG

0.55

0.23–1.35

0.19

0.68

0.45–1.03

0.07

TSF* AG

0.59

0.26–1.38

0.23

0.73

0.50–1.08

0.12

LBM* AG

1.18

0.59–2.37

0.63

0.91

0.62–1.33

0.62

Cre* AG

0.67

0.30–1.47

0.31

0.68

0.46–1.01

0.06

MAMC* AG

0.69

0.31–1.55

0.37

0.66

0.43–1.01

0.06

  1. Abbreviations: CI Confidence interval, HR Hazard ratio, AG Acyl-ghrelin, BMI Body mass index, FM Fat mass, TSF Triceps skinfold, LBM Lean body mass, Cr Creatinine, MAMC Midarm circumference calculated, DM Diabetes mellitus
  2. aAdjusted for age, gender, DM status, dialysis vintage, comorbidity index, smoking, Kt/V and cholesterol
  3. bControlled for the main effects of variables included in interaction analysis