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Table 2 Characteristics of studies reporting vascular access parameters associated with filter life [17, 19–50, 103]

From: Non anti-coagulant factors associated with filter life in continuous renal replacement therapy (CRRT): a systematic review and meta-analysis

Study Name

Sample Size

Design

Description

Inclusion Criteria

Exclusion Criteria

Intervention/Comparison

Control

du Cheyron et al., 2006 [35]

78 patients/193 filters

Retrospective Cohort

Antithrombin administration vs Heparin

Septic shock, CRRT, 1/2001 to 12/2004

Antithrombin cutoff parameters

Antithrombin administration

Regional Heparin

Kim et al. 2011(b) [92]

50 patients/341 circuits

Prospective Observational

Niagara vs Dolphin Catheters for CRRT

CRRT with femoral access

N/A

Niagara 13.5Fr

Controlling for other variables

Kim et al. 2011 [37]

50 patients/341 circuits

Prospective Observational

Insertion side, body position and circuit life

CRRT with femoral access

N/A

Anticoagulation

Controlling for other variables

Chua et al., 2012 [50]

71 patients/539 filters

Retrospective Cohort

Circuit Life in Hepatic Failure with AKI

Age > 18 years, Hepatic Failure, AKI, January 2006 to July 2011

N/A

Multivariate Analysis

Heparin

Morgan et al. 2012 [26]

100 patients/400 filters

Randomised Unblinded Controlled Trial

Catheter Length in CRRT

Upper body catheter, short term CRRT

exist long term catheter, indication for femoral access, systemic anticoagulation, citrate for excess bleeding risk

13.5 Fr Longer Catheter Length

Controlling for other variables

Fealy et al. 2013 [93]

46 patients/254 filters

Prospective Cohort

Comparison of Niagara & Medcomp catheters

CVVH Exposure

IHD

Medcomp 13.5Fr 24 cm O-O

Niagara 13.5Fr 24 cm D-D

Hwang et al., 2013[60]

222 patients/1236 filters

Retrospective Cohort

Nefamostat vs Heparin

CRRT treated patients 1/2004 to 12/2008

deceased within first filter use, paraquat poisoning

APTT (sec)

Controlling for other variables

Mottes et al., 2013 [38]

80 patients/343 filters

Prospective Observational

Process Control Analysis through changing model of care and education

CRRT 7/2007 to 7/2010

N/A

ICU Nurse CRRT and simulation

No Anticoagulation

Brain et al. 2014 [27]

30 patients/221 Filters

Post-hoc analysis of RCT

Citrate vs Heparin

CRRT, AKI criteria

Weight, contra-indication to study arm, pregnancy, previous CRRT, hypothermia, specific mode CRRT

Citrate Anticoagulation

Dolphin 13.5Fr

Crosswell at al. 2014 [24]

131 patients/870 filters

Retrospective Cohort

Circuit Life by Vascular Access Site

CRRT, Vascular Access Data

N/A

Vascular Access Site Comparison

13.5 Fr Shorter Catheter Length

Dunn & Sriram, 2014 [23]

355 patients/1332 filters

Retrospective Cohort

Patient and Treatment Variables on Filter Life

CRRT 1/2008 to 8/2011

N/A

Multivariate Analysis

Nephrology nurse run CRRT

Sponholz et al., 2014 [94]

1621 patients/10643 filters

Retrospective Cohort

Anticoagulation strategies over 5 year period

CRRT, 1/2007 to 12/2012

N/A

Femoral Access

Non-Femoral Access

Wang et al. 2014 [36]

34 patients/126 filters

Prospective Cohort Study

Effect of mobilisation on filter life

CRRT, 8/2011 to 8/2012, temporary vascular access

Permanent vascular access, SLED

Mobilisation

Baseline

Zhang et al., 2015 [39]

23 patients/79 filters

Prospective Observational

Patterns and Mechanisms of artificial kidney failure

Age > 18 years, CRRT, Prismaflex

Non-prismaflex machine, plasma exchange, CRRT duration <24 hours

Stratify filter failure by access pressure

Controlling for other variables