Protective effect of quinacrine against glycerol-induced acute kidney injury in rats

BMC Nephrology

Table 4 Effect of Quinacrine on glycerol induced histopathological changes in kidney (higher scores indicate severe injury)

Groups	Tubular dilatation	Tubular voculation	Tubular necrosis
Control	0	0	0
Glycerol25%	3.37 ± 0.18###	1.43 ± 0.290#	0.875 ± 0.182##
QRN 3 mg/kg + GLY	2.50 ± 0.25*	1.25 ± 0.163	0.812 ± 0.209
QRN 10 mg/kg + GLY	1.87 ± 0.27**	0.81 ± 0.209	0.375 ± 0.125*
QRN 30 mg/kg + GLY	1.37 ± 1**	0.62 ± 0.081*	0.125 ± 0.125**

Effect of quinacrine on glycerol-induced AKI.. Glycerol treated rats developed significant histological changes in kidney tubules. Data expressed in mean ± SE. # P < 0.05, ## P < 0.01 and ### P < 0.001 as compare to control group; *P < 0.05, and ** P < 0.001 as compare to glycerol treated group (G.3)

ISSN: 1471-2369