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Table 2 Parameters of coagulation, fibrinolysis and endothelial function markers in healthy controls and CKD patients

From: Indoxyl sulfate – the uremic toxin linking hemostatic system disturbances with the prevalence of cardiovascular disease in patients with chronic kidney disease

  Factor Controls CKD P value
Coagulation TF [pg/ml] 112 (10 – 316) 270 (45 – 1355) <0.0001
F1 + 2 [nmol/ml] 1.04 (0.66 – 2) 3.42 (0.25 – 14.2) <0.0001
TFPI [ng/ml] 98.4 (62.2 – 165) 78.8 (40.4 – 194) NS
Fibrinolysis PAP [ng/ml] 216 (31 – 541) 466 (83.9 – 1735) 0.0085
uPA [ng/ml] 0.4 (0.1 – 1.1) 1.15 (0.6 – 5) <0.0001
suPAR [ng/ml] 0.07 (0.07 – 0.2) 2.42 (0.6 – 6.8) <0.0001
tPA [ng/ml] 5.05 (2.8 – 8.9) 7.4 (2 – 70) 0.0096
PAI-1 [ng/ml] 24.5 (13 – 79) 55.7 (12.5 – 96.7) 0.0002
Endothelial function vWF [ng/ml] 74.6 ± 9.59 102 ± 13.4 <0.0001
TM [ng/ml] 2.8 ± 1.11 10.1 ± 4.63 <0.0001
sICAM-1 [ng/ml] 226 (128 – 286) 263 (143 – 763) 0.0009
sVCAM-1 [ng/ml] 565 (240 – 986) 912 (288 – 3426) 0.0064
  1. Data are shown as mean ± SD or median (range) depending on their normal or skewed distribution
  2. Abbreviations: TF tissue factor, F1 + 2 prothrombin fragments 1 + 2, TFPI tissue factor pathway inhibitor, PAP plasmin-α2-antiplasmin, uPA urinary plasminogen activator, suPAR soluble urokinase-type plasminogen activator receptor, tPA tissue plasminogen activator, PAI-1 plasminogen activator inhibitor-1, vWF von Willebrand Factor, TM thrombomodulin, sICAM-1 soluble intercellular adhesion molecule-1, sVCAM-1 soluble vascular cell adhesion molecule-1, CKD chronic kidney disease, NS non-significant