Indoxyl sulfate – the uremic toxin linking hemostatic system disturbances with the prevalence of cardiovascular disease in patients with chronic kidney disease

Table 4 The relationships between analyzed hemostatic parameters and cardiovascular disease (CVD) prevalence in patients with chronic kidney disease (CKD)

	vWF	TM	TF	TFPI	suPAR	uPA	tPA	sICAM
TF	−0.009	0.415		0.165	0.283	0.207	0.048	−0.039
TF	NS	0.002		NS	0.044	NS	NS	NS
F1 + 2	−0.316	0.077	−0.007	−0.013	0.069	0.101	−0.287	0.068
F1 + 2	0.023	NS	NS	NS	NS	NS	0.041	NS
TFPI	−0.165	0.556	0.165		0.417	0.210	0.067	0.104
TFPI	NS	0.0001	NS		0.002	NS	NS	NS
PAP	0.324	0.302	0.063	0.342	0.346	0.176	0.192	0.317
PAP	0.020	0.031	NS	0.014	0.013	NS	NS	0.023
uPA	0.241	0.493	0.207	0.210	0.605		0.200	0.372
uPA	NS	0.0002	NS	NS	0.0001		NS	0.007
suPAR	0.479	0.639	0.283	0.417		0.605	0.258	0.525
suPAR	0.0004	0.0001	0.044	0.002		0.0001	NS	0.0001
tPA	0.307	0.146	0.048	0.067	0.258	0.200		0.055
tPA	0.028	NS	NS	NS	NS	NS		NS
PAI-1	0.319	−0.184	−0.173	−0.009	0.028	0.113	0.363	0.039
PAI-1	0.022	NS	NS	NS	NS	NS	0.009	NS
vWF		0.194	−0.008	0.165	0.479	0.242	0.307	0.277
vWF		NS	NS	NS	0.0004	NS	0.028	0.049
TM	0.194		0.415	0.556	0.639	0.493	0.146	0.331
TM	NS		0.002	0.0001	0.0001	0.0002	NS	0.017
sICAM-1	0.277	0.331	−0.039	0.104	0.525	0.372	0.055
sICAM-1	0.049	0.017	NS	NS	0.0001	0.007	NS
sVCAM-1	0.288	0.598	0.282	0.298	0.656	0.407	0.057	0.654
sVCAM-1	0.040	0.0001	0.044	0.033	0.0001	0.003	NS	<0.0001
CVD	6.400	2.865	1.527	1.191	5.802	0.020	0.554	8.881
CVD	0.011	NS	NS	NS	0.016	NS	NS	0.003

Results are shown as Spearman’s rank correlation coefficients (r) or bivariate logistic (χ ²) regression coefficient
Abbreviations: TF tissue factor, F1 + 2 prothrombin fragments 1 + 2, TFPI tissue factor pathway inhibitor, PAP plasmin-α2-antiplasmin, uPA urinary plasminogen activator, suPAR soluble urokinase-type plasminogen activator receptor, tPA tissue plasminogen activator, PAI-1 plasminogen activator inhibitor-1, vWF von Willebrand Factor, TM thrombomodulin, sICAM-1 soluble intercellular adhesion molecule-1, sVCAM-1 soluble vascular cell adhesion molecule-1, CVD cardiovascular disease, NS non-significant

ISSN: 1471-2369