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Table 4 The relationships between analyzed hemostatic parameters and cardiovascular disease (CVD) prevalence in patients with chronic kidney disease (CKD)

From: Indoxyl sulfate – the uremic toxin linking hemostatic system disturbances with the prevalence of cardiovascular disease in patients with chronic kidney disease

  vWF TM TF TFPI suPAR uPA tPA sICAM
TF −0.009 0.415   0.165 0.283 0.207 0.048 −0.039
NS 0.002   NS 0.044 NS NS NS
F1 + 2 −0.316 0.077 −0.007 −0.013 0.069 0.101 −0.287 0.068
0.023 NS NS NS NS NS 0.041 NS
TFPI −0.165 0.556 0.165   0.417 0.210 0.067 0.104
NS 0.0001 NS   0.002 NS NS NS
PAP 0.324 0.302 0.063 0.342 0.346 0.176 0.192 0.317
0.020 0.031 NS 0.014 0.013 NS NS 0.023
uPA 0.241 0.493 0.207 0.210 0.605   0.200 0.372
NS 0.0002 NS NS 0.0001   NS 0.007
suPAR 0.479 0.639 0.283 0.417   0.605 0.258 0.525
0.0004 0.0001 0.044 0.002   0.0001 NS 0.0001
tPA 0.307 0.146 0.048 0.067 0.258 0.200   0.055
0.028 NS NS NS NS NS   NS
PAI-1 0.319 −0.184 −0.173 −0.009 0.028 0.113 0.363 0.039
0.022 NS NS NS NS NS 0.009 NS
vWF   0.194 −0.008 0.165 0.479 0.242 0.307 0.277
  NS NS NS 0.0004 NS 0.028 0.049
TM 0.194   0.415 0.556 0.639 0.493 0.146 0.331
NS   0.002 0.0001 0.0001 0.0002 NS 0.017
sICAM-1 0.277 0.331 −0.039 0.104 0.525 0.372 0.055  
0.049 0.017 NS NS 0.0001 0.007 NS  
sVCAM-1 0.288 0.598 0.282 0.298 0.656 0.407 0.057 0.654
0.040 0.0001 0.044 0.033 0.0001 0.003 NS <0.0001
CVD 6.400 2.865 1.527 1.191 5.802 0.020 0.554 8.881
0.011 NS NS NS 0.016 NS NS 0.003
  1. Results are shown as Spearman’s rank correlation coefficients (r) or bivariate logistic (χ 2) regression coefficient
  2. Abbreviations: TF tissue factor, F1 + 2 prothrombin fragments 1 + 2, TFPI tissue factor pathway inhibitor, PAP plasmin-α2-antiplasmin, uPA urinary plasminogen activator, suPAR soluble urokinase-type plasminogen activator receptor, tPA tissue plasminogen activator, PAI-1 plasminogen activator inhibitor-1, vWF von Willebrand Factor, TM thrombomodulin, sICAM-1 soluble intercellular adhesion molecule-1, sVCAM-1 soluble vascular cell adhesion molecule-1, CVD cardiovascular disease, NS non-significant