Low renal replacement therapy incidence among slowly progressing elderly chronic kidney disease patients referred to nephrology care: an observational study

Table 2 Sub hazard ratios for initiation of renal replacement therapy and death before initiation of renal replacement therapy in a nationwide representative referred cohort of chronic kidney disease patients

Demographics	RRT initiation			Death before RRT initiation
Demographics	SHR	95% CI	P-value	SHR	95% CI	P-value
Age (years)
<65	1.00	ref		1.00	ref
65–75	0.64	0.57–0.72	<0.01	2.48	2.07–2.97	<0.01
>75	0.449	0.40–0.51	<0.01	5.47	4.61–6.49	<0.01
Women	0.72	0.66–0.80	<0.01	0.77	0.70–0.85	<0.01
Primary renal disease
Hypertensive kidney disease	1.00	ref		1.00	ref
Diabetes nephropathy	1.21	1.03–1.41	0.020	0.57	0.45–0.72	<0.01
Glomerulonephritis	1.04	0.91–1.19	0.59	0.78	0.67–0.90	<0.01
Other specified disease	0.67	0.57–0.78	<0.01	1.06	0.94–1.19	0.36
Unknown	1.00	0.97–1.04	0.87	1.20	1.17–1.24	<0.01
Fast progressor (above 18.7% decline/year)	2.24	2.00–2.51	<0.01	1.27	1.13–1.43	<0.01
CKD stage^a
G3b	1.00	ref		1.00	ref
G4	2.04	1.52–2.75	<0.01	0.94	0.80–1.09	0.40
G5	4.05	2.89–5.67	<0.01	0.94	0.75–1.19	0.61
Charlson Score above kidney disease (per 1 unit increase)	1.15	1.04–1.28	0.01	1.06	0.95–1.17	0.31
Body Mass Index (kg/m²)
<18.5	1.08	0.72–1.62	0.72	1.39	0.98–1.96	0.06
18.5–25	1.00	ref		1.00	ref
25–30	0.91	0.81–1.02	0.11	0.96	0.85–1.07	0.46
>30	0.90	0.80–1.02	0.11	0.86	0.76–0.98	0.02

Chronic Kidney Disease (CKD) Renal replacement therapy (RRT), Sub-hazard ratio (SHR) Confidence interval (CI). All variables, estimates are adjusted for all other variables, eGFR after the initial follow-up, current medication, laboratory data, hospital status, region and diet
^aafter the initial one-year baseline period when progression rate was estimated

ISSN: 1471-2369