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Table 2 Sub hazard ratios for initiation of renal replacement therapy and death before initiation of renal replacement therapy in a nationwide representative referred cohort of chronic kidney disease patients

From: Low renal replacement therapy incidence among slowly progressing elderly chronic kidney disease patients referred to nephrology care: an observational study

Demographics RRT initiation Death before RRT initiation
SHR 95% CI P-value SHR 95% CI P-value
Age (years)
 <65 1.00 ref   1.00 ref  
 65–75 0.64 0.57–0.72 <0.01 2.48 2.07–2.97 <0.01
 >75 0.449 0.40–0.51 <0.01 5.47 4.61–6.49 <0.01
Women 0.72 0.66–0.80 <0.01 0.77 0.70–0.85 <0.01
Primary renal disease
 Hypertensive kidney disease 1.00 ref   1.00 ref  
 Diabetes nephropathy 1.21 1.03–1.41 0.020 0.57 0.45–0.72 <0.01
 Glomerulonephritis 1.04 0.91–1.19 0.59 0.78 0.67–0.90 <0.01
 Other specified disease 0.67 0.57–0.78 <0.01 1.06 0.94–1.19 0.36
 Unknown 1.00 0.97–1.04 0.87 1.20 1.17–1.24 <0.01
Fast progressor (above 18.7% decline/year) 2.24 2.00–2.51 <0.01 1.27 1.13–1.43 <0.01
CKD stagea
 G3b 1.00 ref   1.00 ref  
 G4 2.04 1.52–2.75 <0.01 0.94 0.80–1.09 0.40
 G5 4.05 2.89–5.67 <0.01 0.94 0.75–1.19 0.61
Charlson Score above kidney disease (per 1 unit increase) 1.15 1.04–1.28 0.01 1.06 0.95–1.17 0.31
Body Mass Index (kg/m2)
 <18.5 1.08 0.72–1.62 0.72 1.39 0.98–1.96 0.06
 18.5–25 1.00 ref   1.00 ref  
 25–30 0.91 0.81–1.02 0.11 0.96 0.85–1.07 0.46
 >30 0.90 0.80–1.02 0.11 0.86 0.76–0.98 0.02
  1. Chronic Kidney Disease (CKD) Renal replacement therapy (RRT), Sub-hazard ratio (SHR) Confidence interval (CI). All variables, estimates are adjusted for all other variables, eGFR after the initial follow-up, current medication, laboratory data, hospital status, region and diet
  2. aafter the initial one-year baseline period when progression rate was estimated