Table 1 Renal outcome measures
From: Effect of large weight reductions on measured and estimated kidney function
Variable | Baseline | 6 months post-surgery | Change from baseline (95% CI) | p-value |
|---|---|---|---|---|
mGFR (51Cr-EDTA), ml/min (absolute) | 122 (24) | 113 (21) | −9 (−17; −2) | 0.021 |
mGFR (51Cr-EDTA), ml/min/1.73 m2 (corrected for body surface area) | 88 (17) | 90 (16) | 2 (−5; 9) | 0.52 |
Body surface area, m2 | 2.38 (0.22) | 2.14 (0.23) | 0.24 (0.20; 0.28) | <0.001 |
Plasma creatinine, μmol/l | 76 (18) | 66 (12) | −9 (−14; −5) | <0.001 |
Plasma cystatin C, mg/l | 0.94 (0.19) | 0.96 (0.19) | 0.02 (−0.04; 0.07) | 0.61 |
CKD-EPI-sCr eGFR, ml/min/1.73 m2 | 93 (18) | 105 (15) | 12 (6; 17) | <0.001 |
MDRD eGFR, ml/min/1.73 m2 | 84 (21) | 97 (22) | 13 (8; 18) | <0.001 |
CKD-EPI-cysC eGFR, ml/min/1.73 m2 | 89 (19) | 87 (23) | −2 (−8; 4) | 0.51 |
CKD-EPI-sCr-cysC eGFR, ml/min/1.73 m2 | 91 (19) | 96 (21) | 5 (−3; 10) | 0.074 |
24-h systolic blood pressure, mmHg | 122 (14) | 124 (13) | 2 (−5; 10) | 0.56 |
24-h diastolic blood pressure, mmHg | 82 (10) | 79 (11) | −3 (−9; 4) | 0.41 |
Urinary albumin-to-creatinine ratio, mg/g | 6.3 (2.7–8.1) | 4.8 (2.1–5.2) | −23 (−35; −9) % | 0.005 |
Extracellular volume, l | 20.4 (5.9) | 20.4 (6.3) | 0 (−2.5; 2.6) | 0.99 |
Plasma urea, mmol/l | 5.0 (1.5) | 4.3 (1.1) | −0.7 (−1.3; −0.02) | 0.043 |
Plasma calcium, mmol/l | 1.28 (0.04) | 1.28 (0.03) | 0 (−0.02; 0.02) | 0.74 |