Table 4 Multivariate meta-regression analysis for assessment of source of heterogeneity in serum level of cystatin C
Variable | Odds ratio | 95% CI | P |
|---|---|---|---|
Timing of Cystatin C | |||
 Baseline | Ref. | Ref. | --- |
 1-6 h | 2.34 | 0.86-6.34 | 0.09 |
 7-12 h | 1.92 | 0.60-6.15 | 0.26 |
 13-24 h | 1.52 | 0.65-3.56 | 0.32 |
Timing of AKI definition | |||
 Within 24 h | Ref. | Ref. | --- |
 Within 48 h | 0.44 | 0.07-3.00 | 0.39 |
 Within 72 h | 0.16 | 0.02-1.46 | 0.10 |
 More than 72 h | 0.58 | 0.05-6.8 | 0.65 |
AKI definition | |||
 Other | Ref. | Ref. | --- |
 Decrease in eCCl by at least 20% from baseline | 0.08 | 0.002-2.32 | 0.13 |
 50% increase or rise SCr of at least 0.3 mg/dL | 0.06 | 0.004-1.07 | 0.09 |
 GFR < 80 mL/min/1.73 m2 | 0.07 | 0003-1.97 | 0.12 |
 Doubling of SCr from baseline | 0.11 | 0.01-1.3 | 0.08 |
Setting | |||
 Other | Ref. | Ref. | --- |
 Cardiac surgery | 2.52 | 0.45-14.17 | 0.24 |
 PICU admitted | 5.45 | 1.23-24.10 | 0.03 |
Sample size | |||
 ≤30 | Ref. | Ref. | --- |
 >30 | 0.43 | 0.10-1.80 | 0.23 |
Storage degree | |||
 -20 | Ref. | Ref. | --- |
 -70 | 10.03 | 1.61-62.27 | 0.02 |
 -80 | 11.69 | 1.13-121.08 | 0.04 |