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Table 4 Multivariate meta-regression analysis for assessment of source of heterogeneity in serum level of cystatin C

From: Accuracy of cystatin C in prediction of acute kidney injury in children; serum or urine levels: which one works better? A systematic review and meta-analysis

Variable Odds ratio 95% CI P
Timing of Cystatin C
 Baseline Ref. Ref. ---
 1-6 h 2.34 0.86-6.34 0.09
 7-12 h 1.92 0.60-6.15 0.26
 13-24 h 1.52 0.65-3.56 0.32
Timing of AKI definition
 Within 24 h Ref. Ref. ---
 Within 48 h 0.44 0.07-3.00 0.39
 Within 72 h 0.16 0.02-1.46 0.10
 More than 72 h 0.58 0.05-6.8 0.65
AKI definition
 Other Ref. Ref. ---
 Decrease in eCCl by at least 20% from baseline 0.08 0.002-2.32 0.13
 50% increase or rise SCr of at least 0.3 mg/dL 0.06 0.004-1.07 0.09
 GFR < 80 mL/min/1.73 m2 0.07 0003-1.97 0.12
 Doubling of SCr from baseline 0.11 0.01-1.3 0.08
Setting
 Other Ref. Ref. ---
 Cardiac surgery 2.52 0.45-14.17 0.24
 PICU admitted 5.45 1.23-24.10 0.03
Sample size
 ≤30 Ref. Ref. ---
 >30 0.43 0.10-1.80 0.23
Storage degree
 -20 Ref. Ref. ---
 -70 10.03 1.61-62.27 0.02
 -80 11.69 1.13-121.08 0.04
  1. AKI acute kidney injury, CI confidence interval, PICU pediatric intensive care unit, Bold values are significant