Low mean perfusion pressure is a risk factor for progression of acute kidney injury in critically ill patients – A retrospective analysis

Table 2 Multivariable analysis: Risk factors for progression from AKI I to AKI III

Parameter	OR (95% CI)^a	p-value
First arterial lactate following diagnosis of AKI I [mmol/L]	1.45 (1.12–1.89)	0.005
SOFA score on day of AKI I	1.20 (1.05–1.37)	0.01
First DO₂I in 12 h period after diagnosis of AKI I [ml/min/m²]	0.997 (0.994–0.99)	0.01
First calculated MPP	0.995 (0.92–0.99)	0.03
Age [years]	1.02 (0.997–1.05)	0.09
Cumulative fluid balance on day of AKI I [ml]	1.00 (0.99–1.00)	0.98
MAP <65 mmHg for >1 h in first 12 h after diagnosis of AKI I	0.97 (0.48–1.96)	0.93

Abbreviations: CI confidence interval, DO ₂ I oxygen delivery index, MAP mean arterial pressure, MPP mean perfusion pressure, OR odds ratio, SOFA sequential organ failure assessment
^acontrolled for age, oxygen delivery index, arterial lactate concentration, cumulative fluid balance and SOFA score

ISSN: 1471-2369