Low mean perfusion pressure is a risk factor for progression of acute kidney injury in critically ill patients – A retrospective analysis

Table 3 Subgroup analyses: Adjusted association between MPP and progression to AKI III

Patient cohort	OR (95% CI)^a	p-value
No IHD / CCF	0.98 (0.92–1.04)	0.49
IHD / CCF	0.92 (0.86–0.98)	0.019
MAP not <65 mmHg for >1 h	0.96 0.90–1.02)	0.23
MAP <65 mmHg for >1 h	0.93 (0.87–0.98)	0.013
CVP ≤15 mmHg	0.94 (0.87–1.01)	0.08
CVP >15 mmHg	0.98 (0.92–1.04)	0.47
No pre-existing hypertension	0.93 (0.88–0.99)	0.032
Pre-existing hypertension	0.96 (0.90–1.03)	0.259

Abbreviations: AKI acute kidney injury, CCF congestive cardiac failure, IHD ischaemic heart disease, CVP central venous pressure, MAP mean arterial pressure, MPP mean perfusion pressure, OR odds ratio, CI confidence interval
^arepresents the change in odds of progression to AKI III associated with a one unit increase in MPP adjusted for age, oxygen delivery index, arterial lactate concentration, cumulative fluid balance and SOFA score

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