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Table 3 Multivariate analysis: predictors of clinical and microbiological successes in mITT patients (N = 448)a

From: Clinical outcomes of linezolid and vancomycin in patients with nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus stratified by baseline renal function: a retrospective, cohort analysis

Parameter

Variable

P value

Odds ratio (95% CI)

Clinical Success at EOT

Gastrointestinal comorbidity (yes vs. no)

0.069

0.6 (0.4, 1.0)

Vasopressors at baseline (yes vs. no)

0.005

0.4 (0.2, 0.8)

Peripheral vascular disease at baseline (yes vs. no)

0.021

3.0 (1.2, 7.8)

Treatment (linezolid vs vancomycin)

0.014

1.9 (1.1, 3.1)

Bacteremia (yes vs. no)

0.008

0.4 (0.2, 0.8)

Renal function (CLcr, ml/min)b

Overall: 0.775

 

30–80 vs. >80

0.609

0.9 (0.5, 1.5)

<30 vs. >80

0.548

0.7 (0.3, 2.1)

<30 vs. 30–80

0.735

0.8 (0.3, 2.4)

Clinical Success at EOS

Cardiac comorbidity (yes vs. no)

0.037

0.6 (0.4, 1.0)

Vasopressors at baseline (yes vs. no)

0.004

0.4 (0.2, 0.8)

Treatment (linezolid vs vancomycin)c

0.096

1.4 (0.9, 2.2)

Bacteremia (yes vs. no)

0.074

0.5 (0.3, 1.1)

Pathogen type (MRSA mixed vs. MRSA only)

0.034

0.6 (0.4, 1.0)

Renal function (CLcr, ml/min)b

Overall: 0.673

 

30–80 vs. >80

0.506

0.9 (0.5, 1.4)

<30 vs. >80

0.477

0.7 (0.3, 1.8)

<30 vs. 30–80

0.703

0.8 (0.3, 2.2)

Microbiological Success at EOT

Vasopressors at baseline (yes vs. no)

0.018

0.5 (0.3, 0.9)

Treatment (linezolid vs vancomycin)

<0.001

2.6 (1.7, 4.2)

Hepatobiliary comorbidity (yes vs. no)

0.054

0.5 (0.3, 1.0)

Renal function (CLcr, ml/min)b

Overall: 0.550

 

30–80 vs. >80

0.476

0.8 (0.5, 1.4)

<30 vs. >80

0.513

1.4 (0.5, 4.0)

<30 vs. 30–80

0.329

1.7 (0.6, 4.7)

Microbiological Success at EOS

Treatment (linezolid vs vancomycin)

0.040

1.6 (1.0, 2.4)

Chest X-ray (Bilateral vs Unilateral)

0.005

0.5 (0.3, 0.8)

Pleural effusion (yes vs. no)

0.021

1.7 (1.1, 2.7)

Renal function (CLcr, ml/min)b

Overall: 0.691

 

30–80 vs. >80

0.422

0.8 (0.5, 1.3)

<30 vs. >80

0.643

0.8 (0.3, 2.0)

<30 vs. 30–80

0.937

1.0 (0.4, 2.5)

  1. EOT end of treatment, EOS end of study, CLcr creatinine clearance, CI confidence interval
  2. aMissing data were excluded in this model
  3. bRenal function was forced into the model
  4. cTreatment was forced into the model
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BMC Nephrology

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