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Table 5 Renal function over time in the two groups of animals

From: The effects of acute renal denervation on kidney perfusion and metabolism in experimental septic shock

 

T-1

T0

T3

T6

T9

T12

T15

T18

UO, mL/h

 Control

57 ± 31

62 ± 36

71 ± 41

51 ± 16

39 ± 66

3 ± 4*

2 ± 4*

1 ± 2*

 Denervation

66 ± 47

84 ± 70

84 ± 46

53 ± 23*

37 ± 20

10 ± 10*

1 ± 3*

0 ± 0*

Fluid balance, mL/h

 Control

211 ± 79

369 ± 168*

749 ± 145*

1256 ± 180*

1723 ± 195*

2209 ± 284*

2625 ± 304*

3043 ± 311*

 Denervation

260 ± 114

625 ± 221*,#

912 ± 286*

1315 ± 355*

1600 ± 366*

2003 ± 355*

2394 ± 365*

2860 ± 386*

Creatinine clearance, mL/min

 Control

61 ± 17

61 ± 18

80 ± 42

59 ± 42

45 ± 51

5 ± 6*

2.0 ± 0.4*

1 ± 2*

 Denervation

77 ± 43

54 ± 29

62 ± 27

58 ± 32

42 ± 30

7 ± 8*

1.9 ± 0.6*

0 ± 0*

Plasma creatinine, mg/dL

 Control

0.9 ± 0.1

0.9 ± 0.1

0.8 ± 0.1*

0.8 ± 0.1

1.0 ± 0.4

1.6 ± 0.4*

2.0 ± 0.4*

2.5 ± 0.5*

 Denervation

0.7 ± 0.2

0.8 ± 0.2

0.8 ± 0.2

0.7 ± 0.2

0.9 ± 0.3

1.4 ± 0.5*

1.9 ± 0.6*

2.3 ± 0.9*

FF, %

 Control

21 ± 8

22 ± 7

32 ± 14

25 ± 14

21 ± 19

4 ± 4*

1 ± 2*

0 ± 1*

 Denervation

27 ± 10

15 ± 6*

20 ± 10

20 ± 9

27 ± 24

8 ± 7

1 ± 1*

0 ± 0*

TNa+, mmol/min

 Control

8.4 ± 2.4

8.4 ± 2.6

11.4 ± 6.4

9.0 ± 5.4

7.2 ± 7.0

0.8 ± 0.8*

0.3 ± 0.6*

0.1 ± 0.2*

 Denervation

10.5 ± 4.2

7.2 ± 4.1

8.2 ± 3.6

7.8 ± 4.3

5.7 ± 4.3

1.0 ± 1.1*

0.1 ± 0.2*

0.0 ± 0.0*

FENa+, %

 Control

1.4 ± 1.0

1.3 ± 0.5

1.3 ± 0.5

1.0 ± 0.6

0.8 ± 0.7

0.4 ± 0.5

0.0 ± 0.0*

0.0 ± 0.0*

 Denervation

2.2 ± 1.6

1.9 ± 1.5

2.2 ± 1.6

1.4 ± 0.8

1.3 ± 1.1

0.9 ± 1.2

0.0 ± 0.0*

0.0 ± 0.0*

  1. UO urine output, FF filtration fraction, TNa + sodium reabsorption, FENa + fractional excretion of sodium
  2. *p < 0.05 vs. baseline, # p < 0.05 vs. control
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BMC Nephrology

ISSN: 1471-2369

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