Table 1 Parameters of systemic hemodynamics and inflammation
From: Molecular differences in susceptibility of the kidney to sepsis-induced kidney injury
Baseline | 12 h | 18 h | 22 h | |
|---|---|---|---|---|
MAP [mmHg] | ||||
NON-AKI | 93 [86–111] | 80 [72–91] | 76 [73–86] | 78 [70–89] |
AKI | 99 [97–114] | 74 [71–101] | 70 [65–98] | 62 [57–78]* |
CO [ml/kg/min] | ||||
NON-AKI | 90 [73–97] | 102 [64–117] | 105 [82–122] | 159 [97–168]* |
AKI | 99 [90–108] | 139 [100–202] | 173 [133–185] | 94 [72–176] |
SVR [dyne.s.cm−5] | ||||
NON-AKI | 2411 [1822–2844] | 1973 [1401–2059]* | 1382 [1246–1453]* | 778 [583–1765]* |
AKI | 2206 [1998–2821] | 1463 [707–1824]* | 720 [619–1572]* | 854 [610–1453]* |
ITBVI [ml/kg] | ||||
NON-AKI | 23 [21–28] | 27 [22–30] | 22 [21–26] | 23 [22–26] |
AKI | 23 [22–25] | 25 [21–31] | 27 [23–29] | 24 [20–27] |
TNF alfa [pg/g of protein] | ||||
NON-AKI | 1.3 [0.8–1.5] | 4.4 [2.4–5.3]* | 10 [8.9–19.7]* | 14.5 [5.7–23.2]* |
AKI | 1.4 [1.4–3.5] | 20.6 [10.0–24.3]* | 23.4 [6.0–33.8]* | 22.7 [5.3–133.5]* |
IL-6 [pg/g of protein] | ||||
NON-AKI | 4.0 [3.0–5.5] | 5.9 [5.1–11.9] | 33.0 [24.3–119.3]* | 13.2[6.9–543.9]* |
AKI | 2.1 [1.1–6.4] | 217 [164–479]#* | 474 [306–1016]#* | 384 [331–9309]* |