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Table 4 Subgroup analysis for effect of white blood cell on risks of renal function decline, rapid eGFR decline or incident CKD

From: White blood cell count predicts the odds of kidney function decline in a Chinese community-based population

Variable Renal Function Decline Rapid eGFR Decline Incident CKD
Incidence,
n(%)
OR (95% CI) P-interaction Incidence,
n(%)
OR (95% CI) P-interaction Incidence,
n(%)
OR (95% CI) P-interaction
Sex          
 Male 88 (6.5%) 1.10 (0.97, 1.26) 0.5244 244 (18.0%) 1.11 (1.01, 1.21) 0.9709 9 (0.7%) 1.57 (1.06, 2.32) 0.4362
 Female 204 (8.4%) 1.16 (1.06, 1.27)   543 (22.5%) 1.11 (1.04, 1.18)   21 (0.9%) 1.30 (1.02, 1.66)  
Age, years          
  < 60 195 (7.4%) 1.10 (1.00, 1.21) 0.1517 543 (20.5%) 1.07 (1.00, 1.14) 0.0398 7 (0.3%) 1.51 (1.00, 2.27) 0.5985
  ≥ 60 97 (8.6%) 1.23 (1.09, 1.39)   244 (21.7%) 1.20 (1.09, 1.32)   23 (2.0%) 1.32 (1.03, 1.69)  
BMI, kg/m2          
  < 28 212 (7.6%) 1.13 (1.03, 1.23) 0.6299 577 (20.6%) 1.12 (1.06, 1.19) 0.4084 23 (0.8%) 1.30 (1.02, 1.67) 0.4080
  ≥ 28 80 (8.3%) 1.18 (1.02, 1.36)   210 (21.7%) 1.07 (0.96, 1.18)   7 (0.7%) 1.61 (1.04, 2.47)  
Baseline eGFR, mL/min/1.73 m2         
 Low (<102.5) 166 (8.8%) 1.18 (1.07, 1.31) 0.2632 356 (18.9%) 1.13 (1.05, 1.22) 0.4544 28 (1.5%) 1.38 (1.11, 1.72) 0.8913
 High (≥102.5) 126 (6.7%) 1.09 (0.97, 1.22)   430 (22.8%) 1.09 (1.01, 1.17)   2 (0.1%) 1.31 (0.57, 2.97)  
Current smoking         
 No 247 (8.1%) 1.16 (1.07, 1.27) 0.3243 677 (22.1%) 1.11 (1.05, 1.18) 0.9003 27 (0.9%) 1.37 (1.10, 1.70) 0.9942
 Yes 45 (6.3%) 1.06 (0.89, 1.26)   110 (15.5%) 1.10 (0.98, 1.24)   3 (0.4%) 1.37 (0.76, 2.48)  
Current drinking         
 No 238 (8.2%) 1.17 (1.08, 1.28) 0.1173 640 (22.0%) 1.12 (1.05, 1.19) 0.4544 25 (0.9%) 1.36 (1.08, 1.72) 0.9549
 Yes 54 (6.2%) 1.01 (0.84, 1.21)   147 (16.9%) 1.06 (0.95, 1.20)   5 (0.6%) 1.38 (0.86, 2.22)  
Hypertension          
 No 112 (5.8%) 1.12 (0.99, 1.26) 0.6203 346 (17.9%) 1.07 (0.99, 1.16) 0.2295 4 (0.2%) 1.16 (0.67, 2.02) 0.4416
 Yes 180 (9.8%) 1.16 (1.05, 1.28)   441 (24.1%) 1.14 (1.06, 1.22)   26 (1.4%) 1.44 (1.12, 1.84)  
Diabetes mellitus         
 No 207 (6.6%) 1.12 (1.02, 1.23) 0.5148 570 (18.3%) 1.11 (1.05, 1.18) 0.7693 18 (0.6%) 1.45 (1.08, 1.94) 0.5844
 Yes 85 (13.0%) 1.18 (1.04, 1.34)   217 (33.2%) 1.09 (0.99, 1.21)   12 (1.8%) 1.29 (0.94, 1.76)  
Dyslipidemia          
 No 68 (7.4%) 1.19 (1.02, 1.39) 0.5331 186 (20.3%) 1.10 (0.99, 1.22) 0.8334 5 (0.5%) 1.62 (0.95, 2.75) 0.5003
 Yes 215 (7.8%) 1.13 (1.03, 1.23)   583 (21.1%) 1.11 (1.05, 1.18)   25 (0.9%) 1.32 (1.05, 1.67)  
Cardiovascular disease         
 No 240 (7.3%) 1.14 (1.05, 1.24) 0.9617 657 (20.0%) 1.10 (1.04, 1.17) 0.6392 18 (0.5%) 1.44 (1.09, 1.89) 0.5951
 Yes 52 (10.9%) 1.14 (0.96, 1.35)   130 (27.3%) 1.14 (1.00, 1.30)   12 (2.5%) 1.28 (0.91, 1.79)  
Antihypertensive drugs         
 No 165 (6.4%) 1.12 (1.02, 1.24) 0.5696 477 (18.6%) 1.08 (1.01, 1.16) 0.2454 7 (0.3%) 1.06 (0.66, 1.70) 0.2017
 Yes 125 (10.6%) 1.17 (1.04, 1.31)   305 (25.8%) 1.15 (1.06, 1.26)   22 (1.9%) 1.47 (1.16, 1.86)  
Hypoglycemic drugs         
 No 239 (7.1%) 1.14 (1.04, 1.24) 0.7537 648 (19.2%) 1.11 (1.05, 1.18) 0.8791 20 (0.6%) 1.52 (1.16, 2.00) 0.2124
 Yes 52 (13.6%) 1.17 (0.99, 1.38)   138 (36.1%) 1.10 (0.97, 1.25)   10 (2.6%) 1.12 (0.72, 1.74)  
Lipid-lowering drugs         
 No 255 (7.6%) 1.18 (1.09, 1.28) 0.0541 679 (20.4%) 1.13 (1.07, 1.20) 0.0872 24 (0.7%) 1.54 (1.20, 1.96) 0.0677
 Yes 34 (8.6%) 0.94 (0.74, 1.19)   102 (25.7%) 0.99 (0.86, 1.15)   4 (1.0%) 0.84 (0.40, 1.75)  
  1. Variables in the model: age, sex, eGFR at baseline, body mass index, current smoking, current drinking, hypertension, diabetes mellitus, dyslipidemia, history of cardiovascular disease, antihypertensive drugs, hypoglycemic drugs, and lipid-lowering drugs
  2. Abbreviations: eGFR estimated glomerular filtration rate, CKD chronic kidney disease, OR odd ratio, CI confidence interval