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Table 3 Differences between parameters that interact with FGF23 in the CKD stages

From: Deviations from the expected relationship between serum FGF23 and other markers in children with CKD: a cross-sectional study

n = 144 CKD Stage I
n = 59
CKD Stage II
n = 31
CKD Stage III
n = 29
CKD Stage IV
n = 14
CKD Stage V
n = 11
p
Cystatin C eGFR [mL/min/1.73 m2]
Median (IQR)
126.56
(101.85–159.61)
74.65
(69.43–79.08)
42.30
(36.76–53.67)
21.47
(17.87–26.58)
11.53
(10.69–13.76)
0.000*
FGF23 [pg/mL]
Median (IQR)
40.45
(31.66–50.00)
45.19
(34.51–55.32)
63.79
(41.27–162.94)
133.64
(75.05–539.91)
535.44
(158.45–1249.95)
0.000*
Delta FGF23 [pg/mL]
Median (IQR)
1.79
(−8.17 to 11.14)
−6.68
(−15.58 to 7.89)
−25.39
(−81.04 to 14.73)
−144.33
(−276.82 to 82.31)
17.17
(−437.13 to 682.81)
0.111
Phosphate [mmol/L]
Median (IQR)
1.26
(1.07–1.38)
1.25
(1.15–1.38)
1.26
(1.19–1.44)
1.62
(1.37–1.88)
2.18
(1.51–3.17)
0.000*
Ionized Calcium
[mmol/L]
Mean SD
1.15 ± 0.06 1.17 ± 0.10 1.16 ± 0.093 1.10 ± 0.070 1.02 ± 0.083 0.000*
1,25 (OH)2 Vit D [pmol/L]
Median (IQR)
89.00
(70.75–128.25)
79.00
(62.00–121.50)
60.00
(36.50–81.00)
45.50
(21.50–89.25)
11.00
(10.00–34.00)
0.000*
PTH [pmol/L]
Median (IQR)
3.90
(2.80–5.50)
5.10
(3.75–8.20)
9.15
(7.17–12.52)
17.50
(11.52–70.27)
43.65
(7.20–112.65)
0.000*
pH
Mean SD
7.36 ± 0.041 7.34 ± 0.033 7.34 ± 0.052 7.30 ± 0.080 7.39 ± 0.076 0.003*
Bicarbonate
[mmol/L]
Mean SD
26.39 ± 3.27 24.58 ± 3.24 24.30 ± 3.98 28.08 ± 7.47 30.30 ± 4.44 0.000*
CRP
Median (IQR)
1.00
(0.59–3.67)
0.59
(0.56–2.82)
1.55
(0.59–3.60)
0.59
(0.59–4.85)
3.55
(2.55–10.90)
0.010*
  1. *denotes significant associations (p < 0.05)
  2. One-way ANOVA and Kruskal-Wallis test. For a significant p < 0.05