Table 3 Differences between parameters that interact with FGF23 in the CKD stages
n = 144 | CKD Stage I n = 59 | CKD Stage II n = 31 | CKD Stage III n = 29 | CKD Stage IV n = 14 | CKD Stage V n = 11 | p |
|---|---|---|---|---|---|---|
Cystatin C eGFR [mL/min/1.73 m2] Median (IQR) | 126.56 (101.85–159.61) | 74.65 (69.43–79.08) | 42.30 (36.76–53.67) | 21.47 (17.87–26.58) | 11.53 (10.69–13.76) | 0.000* |
FGF23 [pg/mL] Median (IQR) | 40.45 (31.66–50.00) | 45.19 (34.51–55.32) | 63.79 (41.27–162.94) | 133.64 (75.05–539.91) | 535.44 (158.45–1249.95) | 0.000* |
Delta FGF23 [pg/mL] Median (IQR) | 1.79 (−8.17 to 11.14) | −6.68 (−15.58 to 7.89) | −25.39 (−81.04 to 14.73) | −144.33 (−276.82 to 82.31) | 17.17 (−437.13 to 682.81) | 0.111 |
Phosphate [mmol/L] Median (IQR) | 1.26 (1.07–1.38) | 1.25 (1.15–1.38) | 1.26 (1.19–1.44) | 1.62 (1.37–1.88) | 2.18 (1.51–3.17) | 0.000* |
Ionized Calcium [mmol/L] Mean SD | 1.15 ± 0.06 | 1.17 ± 0.10 | 1.16 ± 0.093 | 1.10 ± 0.070 | 1.02 ± 0.083 | 0.000* |
1,25 (OH)2 Vit D [pmol/L] Median (IQR) | 89.00 (70.75–128.25) | 79.00 (62.00–121.50) | 60.00 (36.50–81.00) | 45.50 (21.50–89.25) | 11.00 (10.00–34.00) | 0.000* |
PTH [pmol/L] Median (IQR) | 3.90 (2.80–5.50) | 5.10 (3.75–8.20) | 9.15 (7.17–12.52) | 17.50 (11.52–70.27) | 43.65 (7.20–112.65) | 0.000* |
pH Mean SD | 7.36 ± 0.041 | 7.34 ± 0.033 | 7.34 ± 0.052 | 7.30 ± 0.080 | 7.39 ± 0.076 | 0.003* |
Bicarbonate [mmol/L] Mean SD | 26.39 ± 3.27 | 24.58 ± 3.24 | 24.30 ± 3.98 | 28.08 ± 7.47 | 30.30 ± 4.44 | 0.000* |
CRP Median (IQR) | 1.00 (0.59–3.67) | 0.59 (0.56–2.82) | 1.55 (0.59–3.60) | 0.59 (0.59–4.85) | 3.55 (2.55–10.90) | 0.010* |