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Table 4 Binary Logistic Regression analysis of five models assessing for collinearity as described in the text

From: Deviations from the expected relationship between serum FGF23 and other markers in children with CKD: a cross-sectional study

MODEL 1. Condition: FGF23 > 230 pg/mL
In the presence of: Phosphate, 1,25 (OH)2 Vit D, PTH and CKD Stage.
Parameter SE OR (CI 95%) p
Phosphate [mmol/L]
Below 1.60
0.948 0.056
(0.009–0.357)
0.002*
1,25 (OH)2 Vit D [pmol/L]
Over 50
1.033 0.400
(0.053–3.028)
0.375
PTH [pmol/L] 0.016 1.000
(0.969–1.032)
0.968
CKD Stage Cystatin C eGFR [mL/min/1.73 m2] 0.483 2.940
(1.141–7.575)
0.026*
MODEL 2. Condition: FGF23 > 230 pg/mL
In the presence of: Bicarbonate, 1,25 (OH)2 Vit D, PTH and Ionized Calcium.
Parameter SE OR (CI 95%) p
Bicarbonate [mmol/L] 0.107 0.936
(0.760–1.154)
0.536
1,25 (OH)2 Vit D [pmol/L]
Over 50
0.850 0.138
(0.026–0.728)
0.020*
PTH [pmol/L] 0.014 1.026
(0.998–1.053)
0.066
Ionized Calcium
[mmol/L]
4.753 0.002
(0.000–23.520)
0.195
MODEL 3. Condition: FGF23 > 230 pg/mL
In the presence of: 1,25 (OH)2 Vit D, PTH, Ionized Calcium and Phosphate.
Parameter SE OR (CI 95%) p
1,25 (OH)2 Vit D [pmol/L]
Over 50
0.975 0.100
(0.015–0.673)
0.018*
PTH [pmol/L] 0.016 1.014
(0.983–1.047)
0.379
Ionized Calcium
[mmol/L]
4.431 7.980
(0.001–467.56)
0.641
Phosphate [mmol/L]
Below 1.60
0.923 0.045
(0.007–0.277)
0.001*
MODEL 4. Condition: FGF23 > 230 pg/mL
In the presence of: Bicarbonate, CRP, 1,25 (OH)2 Vit D and PTH.
Parameter SE OR (CI 95%) p
Bicarbonate [mmol/L] 0.082 1.021
(0.868–1.200)
0.804
CRP 0.038 0.987
(0.917–1.063)
0.735
1,25 (OH)2 Vit D [pmol/L]
Over 50
0.788 0.110
(0.024–0.517)
0.005*
PTH [pmol/L] 0.014 1.027
(1.000–1.055)
0.053
MODEL 5. Condition: pH > 7.35
In the presence of: FGF23, Ionized Calcium, Bicarbonate and CKD Stage.
Parameter SE OR (CI 95%) p
FGF23 [pg/mL] 0.005 1.009
(1.000–1.019)
0.047*
Ionized Calcium
[mmol/L]
3.325 0.028
(0.000–18.791)
0.281
Bicarbonate [mmol/L] 0.064 0.913
(0.806–1.035)
0.155
CKD Stage Cystatin C eGFR [mL/min/1.73 m2] 0.252 0.588
(0.359–0.964)
0.035*
  1. *denotes significant associations (p < 0.05)
  2. SE Standard error, OR Odds ratio, CI Confident interval. For a significant p value <0.05