Table 3 Odds ratios (ORs) with 95% of confidence interval (CI) of metformin-associated lactic acidosis (MALA)-related mortality for potentially predictive factors by univariable and multiple logistic regression
Variable | Deceased/survivor (total) | Crude analysis OR (95% CI) | p-value | Multiple-adjustment OR (95% CI) (deceased/survivor: 23/152, total = 175) | p-value |
|---|---|---|---|---|---|
Blood lactate (mmol/L) | 36/198 (234) | 1.08 (1.03, 1.13) | 0.001 | 1.09 (1.02, 1.17) | 0.009 |
Age (yr) | 40/212 (252) | 0.99 (0.97, 1.01) | 0.297 | 1.03 (0.98, 1.08) | 0.236 |
Sex (ref: male) | 41/208 (249) | 0.44 (0.22, 0.87) | 0.019 | 0.22 (0.08, 0.67) | 0.007 |
RRT modality | 41/210 (251) | ||||
IRRT | Ref | — | Ref | — | |
PIRRT | 1.72 (0.52, 5.70) | 0.376 | 1.28 (0.15, 10.7) | 0.818 | |
CRRT | 2.36 (1.01, 5.52) | 0.048 | 3.13 (0.81, 12.1) | 0.098 | |
PD | 9.63 (1.67, 55.8) | 0.012 | 3.11 (0.10, 96.1) | 0.517 | |
Metformin usage | 36/196 (232) | ||||
Suicidal (Ref: regular use) | 2.19 (1.02, 4.70) | 0.044 | 0.80 (0.15, 4.23) | 0.790 | |
Peak creatinine level (mg/dl) | 28/183 (211) | 0.80 (0.70, 0.91) | 0.001 | 0.77 (0.65, 0.91) | 0.003 |