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Table 5 Rating the Quality of Evidences by GRADE

From: A comparison of early versus late initiation of renal replacement therapy for acute kidney injury in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials

Outcomes Studies No. of Participants Effect Quality Importance Recommendation grade
Early RRT Late RRT RR/RD (95% CI) Absolute
Overall mortality 9 338/827 (40.9%) 344/809 (42.5%) RR 0.98 (0.78 to 1.23) 9 fewer per 1000 (from 94 fewer to 98 more) Ο
Moderate
Critical Weak
ICU LOS of survivors 4 301 283 - MD 0.52 lower (2.6 lower to 1.56 higher) ΟΟ
low
Important Weak
Hospital LOS of survivors 4 300 282 - MD 0.46 lower (7.18 lower to 6.25 higher) ΟΟ
low
Important Weak
Renal function recovery 7 430/769 (55.9%) 405/747 (54.2%) RR 1.02 (0.88 to 1.19) 11 more per 1000 (from 65 fewer to 103 more) ΟΟ
low
Important Weak
Renal recovery time 2 163 124 - MD 0.73 higher (2.09 lower to 3.56 higher) ΟΟ
low
Important Weak
Duration of RRT 3 316 260 - MD 1.43 higher (1.75 lower to 4.61 higher) ΟΟ
low
Important Weak
RRT dependence 7 19/447 (4.3%) 23/427 (5.4%) RR 0.76 (0.42 to 1.37) 13 fewer per 1000 (from 31 fewer to 20 more) ΟΟ
low
Important Weak
Mechanical ventilation time 3 294 267 - MD 0.95 lower (3.54 lower to 1.64 higher) ΟΟ
low
Important Weak
  1. Abbreviations: RRT renal replacement therapy, ICU intensive care unit, LOS length of stay, GRADE Grading of Recommendations Assessment, Development, and Evaluation, No number, CI confidence interval, RD relative difference, RR risk ratio, MD mean difference