Table 5 Rating the Quality of Evidences by GRADE
Outcomes | Studies | No. of Participants | Effect | Quality | Importance | Recommendation grade | ||
|---|---|---|---|---|---|---|---|---|
Early RRT | Late RRT | RR/RD (95% CI) | Absolute | |||||
Overall mortality | 9 | 338/827 (40.9%) | 344/809 (42.5%) | RR 0.98 (0.78 to 1.23) | 9 fewer per 1000 (from 94 fewer to 98 more) | ⊕ ⊕ ⊕Ο Moderate | Critical | Weak |
ICU LOS of survivors | 4 | 301 | 283 | - | MD 0.52 lower (2.6 lower to 1.56 higher) | ⊕ ⊕ ΟΟ low | Important | Weak |
Hospital LOS of survivors | 4 | 300 | 282 | - | MD 0.46 lower (7.18 lower to 6.25 higher) | ⊕ ⊕ ΟΟ low | Important | Weak |
Renal function recovery | 7 | 430/769 (55.9%) | 405/747 (54.2%) | RR 1.02 (0.88 to 1.19) | 11 more per 1000 (from 65 fewer to 103 more) | ⊕ ⊕ ΟΟ low | Important | Weak |
Renal recovery time | 2 | 163 | 124 | - | MD 0.73 higher (2.09 lower to 3.56 higher) | ⊕ ⊕ ΟΟ low | Important | Weak |
Duration of RRT | 3 | 316 | 260 | - | MD 1.43 higher (1.75 lower to 4.61 higher) | ⊕ ⊕ ΟΟ low | Important | Weak |
RRT dependence | 7 | 19/447 (4.3%) | 23/427 (5.4%) | RR 0.76 (0.42 to 1.37) | 13 fewer per 1000 (from 31 fewer to 20 more) | ⊕ ⊕ ΟΟ low | Important | Weak |
Mechanical ventilation time | 3 | 294 | 267 | - | MD 0.95 lower (3.54 lower to 1.64 higher) | ⊕ ⊕ ΟΟ low | Important | Weak |