Urine neutrophil gelatinase-associated lipocalin to predict renal response after induction therapy in active lupus nephritis

Table 2 Baseline conventional renal biomarkers with renal response after induction therapy

	Complete response	Partial response	Non-response	P value
	(n = 17)	(n = 40)	(n = 11)	P value
Renal activity index	7 (5, 11)	9 (6, 12)	8 (6, 10)	0.760
Renal chronicity index	0 (0, 3)^a,b	2 (0, 3)^c	3 (3, 4)^a,b,c	0.008
SLEDAI score	12 (10, 14)^a	10 (8, 12)^a	12 (8, 16)	0.018
Renal SLEDAI score	8 (4, 8)	4 (4, 8)	8 (8, 12)	0.077
Positive Anti-dsDNA (%)	17 (100%)	39 (97.5%)	11 (100%)	0.705
Serum complement C3 levels (g/L)	0.4 (0.3, 0.6)^a,b	0.8 (0.5, 1)^a,c	1.3 (0.9, 1.4) ^a,b,c	0.001
Hematocrit (%)	29 (13.1, 33.6)	30.3 (11.9, 35.8)	32.9 (14.9, 36)	0.568
Serum albumin (g/dL)	2.9 (2.3, 3.3)	3 (2, 3)	3 (3, 3.2)	0.573
Serum creatinine (mg/dL)	0.8 (0.6, 0.9)	0.9 (0.7, 1.2)	0.7 (0.7, 1.2)	0.553
Estimated GFR (mL/min/1.73 m²)	98.5 (85.3, 118.5)	84.2 (59.2, 111.7)	96.2 (53.7, 120.2)	0.467
UPCR (g/g creatinine)	3.1 (2, 4.5)^a	5.5 (3.9, 8.6)^a	4.6 (2.1, 6.9)	0.011

Abbreviations Anti-dsDNA anti-double-stranded DNA antibody, GFR glomerular filtration rate, RAAS; renin angiotensin aldosterone system, SLEDAI systemic lupus erythematosus disease activity index, UPCR urine protein creatinine ratio
Values for categorical variables are given as median [interquartile range]
P-value corresponds to ANOVA test, Kruskal-Wallis test (comparison 3 groups) and Mann–Whitney U (comparison 2 groups), ^acomplete response vs. partial response, ^bcomplete response vs. nonresponse and ^cpartial response vs. nonresponse
Define term of complete response is return of serum creatinine to previous baseline, plus a decline in the UPCR to <500 mg/g
Define term of partial response is stabilization (±25%), or improvement of SCr, but not to normal, plus a ≥ 50% decrease in UPCR. If there was nephrotic-range proteinuria, improvement requires a ≥ 50% reduction in UPCR, and a UPCR <3000 mg/g
Define term of non-response is a sustained 25% increase in serum creatinine or a < 50% decrease in UPCR

ISSN: 1471-2369