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Table 2 Baseline conventional renal biomarkers with renal response after induction therapy

From: Urine neutrophil gelatinase-associated lipocalin to predict renal response after induction therapy in active lupus nephritis

  Complete response Partial response Non-response P value
(n = 17) (n = 40) (n = 11)
Renal activity index 7 (5, 11) 9 (6, 12) 8 (6, 10) 0.760
Renal chronicity index 0 (0, 3)a,b 2 (0, 3)c 3 (3, 4)a,b,c 0.008
SLEDAI score 12 (10, 14)a 10 (8, 12)a 12 (8, 16) 0.018
Renal SLEDAI score 8 (4, 8) 4 (4, 8) 8 (8, 12) 0.077
Positive Anti-dsDNA (%) 17 (100%) 39 (97.5%) 11 (100%) 0.705
Serum complement C3 levels (g/L) 0.4 (0.3, 0.6)a,b 0.8 (0.5, 1)a,c 1.3 (0.9, 1.4) a,b,c 0.001
Hematocrit (%) 29 (13.1, 33.6) 30.3 (11.9, 35.8) 32.9 (14.9, 36) 0.568
Serum albumin (g/dL) 2.9 (2.3, 3.3) 3 (2, 3) 3 (3, 3.2) 0.573
Serum creatinine (mg/dL) 0.8 (0.6, 0.9) 0.9 (0.7, 1.2) 0.7 (0.7, 1.2) 0.553
Estimated GFR (mL/min/1.73 m2) 98.5 (85.3, 118.5) 84.2 (59.2, 111.7) 96.2 (53.7, 120.2) 0.467
UPCR (g/g creatinine) 3.1 (2, 4.5)a 5.5 (3.9, 8.6)a 4.6 (2.1, 6.9) 0.011
  1. Abbreviations Anti-dsDNA anti-double-stranded DNA antibody, GFR glomerular filtration rate, RAAS; renin angiotensin aldosterone system, SLEDAI systemic lupus erythematosus disease activity index, UPCR urine protein creatinine ratio
  2. Values for categorical variables are given as median [interquartile range]
  3. P-value corresponds to ANOVA test, Kruskal-Wallis test (comparison 3 groups) and Mann–Whitney U (comparison 2 groups), acomplete response vs. partial response, bcomplete response vs. nonresponse and cpartial response vs. nonresponse
  4. Define term of complete response is return of serum creatinine to previous baseline, plus a decline in the UPCR to <500 mg/g
  5. Define term of partial response is stabilization (±25%), or improvement of SCr, but not to normal, plus a ≥ 50% decrease in UPCR. If there was nephrotic-range proteinuria, improvement requires a ≥ 50% reduction in UPCR, and a UPCR <3000 mg/g
  6. Define term of non-response is a sustained 25% increase in serum creatinine or a < 50% decrease in UPCR