Bone turnover markers are associated with bone density, but not with fracture in end stage kidney disease: a cross-sectional study

Table 2 Univariate correlations between biochemical markers of bone turnover and characteristics of adult kidney transplantation candidates

	BSAP		P1NP		TRAP 5b		CTX		NTX
	rho		rho		rho		rho		rho
Age, yrs	−0.16	(†)	−0.18	†	0.01		−0.19	†	−0.19	†
Weight, kg	−0.18	†	−0.22	†	−0.14	(†)	−0.14	(†)	−0.18	†
Body mass index, kg/cm²	−0.17	†	−0.22	†	−0.11		−0.15	(†)	−0.17	†
Estimated glomerular filtration rate (pre-dialysis only, n = 98)	0.16		−0.01		−0.00		−0.26	†	−0.30	†
Parathyroid hormone, ρmol/L	0.30	‡	0.37	‡	0.45	‡	0.42	‡	0.45	‡
Ionized calcium, mmol/L	−0.18	†	−0.23	†	−0.12		−0.17	†	−0.17	†
Phosphate, mmol/L	−0.11		−0.03		−0.10		0.04		0.13
Alkaline phosphatase, U/L	0.72	‡	0.43	‡	0.35	‡	0.38	‡	0.34	‡
25-OH-vitamin D₂ + D₃, nmol/L	−0.02		−0.04		0.09		−0.05		−0.08
Lumbar spine BMD, mg/cm³	0.05		0.07		−0.08		0.03		−0.04
Lumbar spine Z-score	0.01		0.01		−0.06		−0.05		−0.13
Total hip BMD, mg/cm³	−0.20	†	−0.12		−0.20	†	−0.09		−0.15	(†)
Total hip Z-score	−0.27	‡	−0.22	†	−0.19	†	−0.12		−0.20	†
Femoral neck BMD, mg/cm³	−0.10		−0.04		−0.12		0.01		−0.09
Femoral neck Z-score	−0.22	†	−0.22	†	−0.18	†	−0.11		−0.20	†

Data are Spearman’s rho with corresponding p-values, (†) = p < 0.10, † = p < 0.05, ‡ = p < 0.001
Abbr.: BMD Bone mineral density, BSAP Bone specific alkaline phosphatase, P1NP Procollagen type 1 N-terminal propeptide, TRAP5b Tartrate resistant alkaline phosphatase type 5b, CTX C-terminal telopeptide of type I collagen, NTX N-terminal telopeptide of type I collagen

ISSN: 1471-2369