Bone turnover markers are associated with bone density, but not with fracture in end stage kidney disease: a cross-sectional study

Table 4 Bone density measurements in adult kidney transplantation candidates with and without prevalent fragility fracture

	No fracture (n = 129)	Any fracture (n = 28)		Vertebral fracture (n = 17)		Non-vertebral fracture (n = 16)
Volumetric BMD, mg/cm³
Lumbar spine	126 ± 38	103 ± 37	†	90 ± 28	‡	106 ± 44	(†)
Total hip	237 ± 43	196 ± 35	‡	201 ± 33	†	184 ± 33	‡
Femoral neck	242 ± 50	195 ± 37	‡	198 ± 37	†	180 ± 34	‡
Areal BMD, mg/cm²
Total hip	0.71 ± 0.12	0.61 ± 0.10	‡	0.63 ± 0.10	†	0.56 ± 0.09	‡
Femoral neck	0.60 ± 0.10	0.51 ± 0.09	‡	0.52 ± 0.10	†	0.46 ± 0.07	‡
Z-score
Lumbar spine	−0.30 ± 1.37	−1.11 ± 1.21	†	−1.29 ± 0.84	†	−0.96 ± 1.46
Total hip	−1.08 ± 1.05	−0.94 ± 1.04	‡	−1.45 ± 0.80		−2.42 ± 0.88	‡
Femoral neck	−0.91 ± 0.94	−1.77 ± 0.86	‡	−1.41 ± 0.79		−2.26 ± 0.60	‡
T-score
Lumbar spine	−1.77 ± 1.43	−2.60 ± 1.44	†	−3.13 ± 1.04	‡	−2.44 ± 1.71
Total hip	−1.79 ± 1.05	−2.73 ± 0.89	‡	−2.47 ± 0.84	†	−3.17 ± 0.78	‡
Femoral neck	−1.74 ± 0.93	−2.60 ± 0.79	‡	−2.44 ± 0.86	†	−3.04 ± 0.64	‡
Femoral neck strength
Buckling ratio	9.52 ± 3.05	12.9 ± 3.8	‡	12.7 ± 3.8	‡	14.1 ± 4.0	‡
Cross-sectional moment of inertia, mm⁴	7.50 ± 2.39	7.77 ± 3.33		8.52 ± 3.69		6.94 ± 3.66

Data are mean ± SD, Student’s t test: † = p < 0.05 and ‡ = p < 0.001 compared to non-fractured patients

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