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Table 3 Univariate and Multivariate Cox proportional hazard analysis of overall mortality

From: Serum osteoprotegerin in prevalent hemodialysis patients: associations with mortality, atherosclerosis and cardiac function

 

Univariate analysis

Multivariate analysis

Variable

HR (CI 95%)

P-Value

HR (CI 95%)

P-Value

Age (years)

1.052 (1.032–1.072)

<0.001

1.031 (1.002–1.06)

0.036

Charlson Comorbidity Index

1.305 (1.194–1.427)

<0.001

1.254 (1.075–1.462)

0.004

Previous cardiovascular disease (yes/no)

2.185 (1.30–3.65)

0.003

-

 

Incident cardiovascular disease (yes/no)

2.654 (1.646–4.279)

<0.001

-

 

Left Ventricular Hypertrophy (yes/no)

1.764 (1.093–2.845)

0.002

-

 

Previous Kidney Transplant (yes/no)

0.374 (0.186–0.751)

0.006

-

 

Interdialytic weight gain (kg)

0.764 (0.579–1.007)

0.056

-

 

Dyslipidaemia (yes/no)

1.255 (0.793–1.985)

0.332

-

 

Diabetes Mellitus (yes/no)

1.401 (0.861–2.28)

0.174

-

 

Hypertension (yes/no)

1.32 (0.606–2.878)

0.485

-

 

Smoking (yes/no)

2.185 (1.376–3.47)

0.001

2.122 (1.251–3.599)

0.005

Systolic Blood Pressure (mmHg)

0.993 (0.983–1.004)

0.191

-

 

Diastolic Blood Pressure (mmHg)

0.975 (0.957–0.994)

0.010

-

 

Mean Blood Pressure (mmHg)

0.983 (0.968–0.999)

0.032

-

 

Statin treatment (yes/no)

1.516 (0.929–2.473)

0.096

-

 

Osteoprotegerin (highesttertile)

1.9 (1.203–2.999)

0.006

1.957 (1.123–3.411)

0.018

Calcium (mg/dl)

1.136 (0.9–1.434)

0.284

-

 

Phosphate (mg/dl)

0.868 (0.745–1.013)

0.072

-

 

iPTH (pg/ml)

0.999 (0.998–1.000)

0.114

-

 

Fetuin-A (ng/ml)

0.994 (0.984–1.004)

0.230

-

 

Albumin (g/l)

0.884 (0.844–0.925)

<0.001

0.886 (0.837–0.937)

< 0.001

C-reactive protein (mg/dl)

1.17 (1.09–1.252)

<0.001

-

 

Adiponectin (μg/ml)

1.003 (0.973–1.033)

0.867

-

 

IL-18 (pg/ml)

1.0 (1.00–1.001)

0.011

1.061 (1.036–1.087)

<0.001

Troponin I (ng/ml)

12.626 (3.795–42.01)

<0.001

3.894 (1.048–14.462)

0.042

BNP (pg/ml)

1.0 (1.0–1.001)

0.001

-

 

LV ejection fraction (%)

0.966 (0.945–0.987)

0.002

-

 
  1. Significant results (p<0.05) are in bold
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BMC Nephrology

ISSN: 1471-2369

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