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Table 4 Association analysis of genetic polymorphisms of the EDN2 gene and cardiovascular disease susceptibility in end-stage renal disease patients

From: Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure

   Cardiovascular disease susceptibility Recessive
rs number Genotype Cases (%) Control (%) OR (95% CI) p value q-value
rs11572340 AA 1 (0.9%) 0 (0%) 0.74 (0.14 ~ 3.85) 0.708 0.796
AC 5 (4.3%) 2 (2.9%) 1   
CC 109 (94.8%) 66 (97.1%) 1   
rs11210278 TT 8 (9.9%) 7 (18.9%) 0.17 (0.03 ~ 0.88) 0.035 0.126
TC 30 (37.0%) 9 (24.3%) 1   
CC 43 (53.1%) 21 (56.8%) 1   
rs2759257 AA 0 (0%) 0 (0%) - NA NA
AC 17 (15.3%) 6 (9.4%) 1   
CC 94 (84.7%) 58 (90.6%) 1   
rs11572377 GG 2 (1.7%) 1 (1.4%) 0.88 (0.07 ~ 11.11) 0.920 0.953
GC 10 (8.6%) 2 (2.8%) 1   
CC 104 (89.7%) 69 (95.8%) 1   
  1. p values were adjusted for age, sex, smoking, diabetes, hypertension, pre-existing cardiovascular events, hemoglobin, albumin, ferritin, and the erythropoietin resistance index. p and q-values of <0.05 are shown in bold. q-values of <0.05 were considered statistically significant after correction for multiple testing. OR, odds ratio; CI, confidence interval