Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure

BMC Nephrology

Table 4 Association analysis of genetic polymorphisms of the EDN2 gene and cardiovascular disease susceptibility in end-stage renal disease patients

		Cardiovascular disease susceptibility			Recessive
rs number	Genotype	Cases (%)	Control (%)	OR (95% CI)	p value	q-value
rs11572340	AA	1 (0.9%)	0 (0%)	0.74 (0.14 ~ 3.85)	0.708	0.796
	AC	5 (4.3%)	2 (2.9%)	1
	CC	109 (94.8%)	66 (97.1%)	1
rs11210278	TT	8 (9.9%)	7 (18.9%)	0.17 (0.03 ~ 0.88)	0.035	0.126
	TC	30 (37.0%)	9 (24.3%)	1
	CC	43 (53.1%)	21 (56.8%)	1
rs2759257	AA	0 (0%)	0 (0%)	-	NA	NA
	AC	17 (15.3%)	6 (9.4%)	1
	CC	94 (84.7%)	58 (90.6%)	1
rs11572377	GG	2 (1.7%)	1 (1.4%)	0.88 (0.07 ~ 11.11)	0.920	0.953
	GC	10 (8.6%)	2 (2.8%)	1
	CC	104 (89.7%)	69 (95.8%)	1

p values were adjusted for age, sex, smoking, diabetes, hypertension, pre-existing cardiovascular events, hemoglobin, albumin, ferritin, and the erythropoietin resistance index. p and q-values of <0.05 are shown in bold. q-values of <0.05 were considered statistically significant after correction for multiple testing. OR, odds ratio; CI, confidence interval

ISSN: 1471-2369