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Fig. 1 | BMC Nephrology

Fig. 1

From: Thymosin β4 alleviates renal fibrosis and tubular cell apoptosis through TGF-β pathway inhibition in UUO rat models

Fig. 1

Effects of different doses of Tβ4 on the pathological changes in kidney tissue in a rat model of UUO. a In the sham group, regular arrangement of tissue structures of the kidney with normal glomerulus and renal tubule. b In the UUO group, severe atrophy of the glomerulus, diffusely widened capsule area, enlarged tubular cavity, vacuolar degeneration, and swollen epithelial cells in the proximal convoluted tubule around the medullary loop, exfoliated epithelial cells in the area with severe pathological changes, disrupted and atrophy renal interstitial tissue, and fibrosis were observed. c The pathological damage was alleviated in the UUO + low-dose Tβ4 group. d The damages were further alleviated in the UUO + high-dose Tβ4 group. Periodic Acid-Schiff staining ×200 magnification

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BMC Nephrology

ISSN: 1471-2369

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