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Fig. 3 | BMC Nephrology

Fig. 3

From: Uric acid causes kidney injury through inducing fibroblast expansion, Endothelin-1 expression, and inflammation

Fig. 3

Uric acid treatment upregulated ET-1 mRNA, TGF-β1 and α-SMA protein expression with demonstrated myofibroblast formation. a Real Time PCR (qRT-PCR) quantification showed increase of ET-1 mRNA in UA group. b, c Westernblot representative picture and densitometry analysis revealed higher expression of TGFβ1 and αSMA protein expression in UA group. Allopurinol treatment induced downregulation of the protein expression especially in UAL14 group. d Immunohistochemical staining of αSMA (400× magnification) to examine positive staining in interstitial areas in UA14 group which represented some myofibroblast expansion. *p < 0.05 VS control group; #p < 0.05 VS UA14 group, † VS UA7 group

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BMC Nephrology

ISSN: 1471-2369

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