Fig. 1

Bar graphs show plasma creatinine (a), urea (b), blood hemoglobin (c), and 24-h urine protein excretion (d) in rats ingesting normal diet (Control; n = 12), 0.3% adenine diet (Ade; n = 20), Ade + 50 mg/kg/day sitaxentan (Ade + S; n = 16), Ade + 20 mg/kg/day cinacalcet (Ade + C; n = 16), and Ade + sitaxentan + cinacalcet (Ade + SC; n = 16); mean ± confidence interval; ^* P < 0.05 vs. Control, ^† P < 0.05 vs. Ade, ‡P < 0.05 vs. Ade + SC