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Table 4 Performance of the CRONICAS-CKD risk score for undiagnosed CKD using CRONICAS dataset

From: Risk score for first-screening of prevalent undiagnosed chronic kidney disease in Peru: the CRONICAS-CKD risk score

Total score

Youden Index

Sensitivity

Specificity

PPV

NPV

Correctly classified

LR+

LR-

 

Complete Risk Score

≥ 0

0%

100.0%

0.0%

3.4%

3.4%

1.00

≥ 1

27.7%

100.0%

27. 7%

4.6%

100.0%

30.1%

1.4

0.00

≥ 2

52.5%

82.5%

70.0%

8.8%

99.1%

70.4%

2.8

0.3

≥ 3

50.7%

60.0%

90.7%

18.3%

98.5%

89.6%

6.4

0.4

≥ 4

16.1%

17.5%

98.6%

29.8%

97.2%

95.8%

12.1

0.8

 

laboratory-free Risk Score

≥ 0

0%

100.0%

00.0%

3.4%

3.4%

1.0

≥ 1

28.3%

98.8%

29.6%

4.7%

99.9%

31.9%

1.4

0.0

≥ 2

52.0%

80.0%

72.0%

9.1%

99.0%

72.3%

2.9

0.3

≥ 3

41.3%

48.8%

92.6%

18.7%

98.1%

91.1%

6.6

0.6

  1. PPV Positive predictive value, NPV Negative predictive value, LR+ Positive likelihood ratio, LR- Negative likelihood ratio
  2. PPV and NPV were calculated with a CKD prevalence of 3.38%. At a cut-off point of 2, the areas under the ROC were similar between the complete and laboratory-free risk scores (76.24% versus 75.99%, P = 0.784). The italicized figures highlight the characteristics at the proposed cut-off point